
Matteo Gastaldi
@mgastaldi85
ID: 1295063167010316288
16-08-2020 18:21:44
38 Tweet
91 Followers
77 Following

Clinical, prognostic and pathophysiological implications of MOG-IgG detection in the CSF: the importance of intrathecal MOG-IgG synthesis jnnp.bmj.com/content/early/⦠Check out our new study on MOG IgG intrathecal synthesis! Congrats to Giacomo Greco on his first Journal of Neurology, Neurosurgery and Psychiatry paper




Check it out our latest review in European Journal of Immunology on GuillaināBarrĆ© syndrome #GBS, exploring recent advances in its #immunopathology and novel clinical implications, building on our recent discovery of #Tcell immunity involvement. doi.org/10.1002/eji.20ā¦

In pts with chronic seizures and suspected "autoimmune epilepsy", we found low yield of routine CSF analysis. In such pts an autoimmune cause is rare; most relevant ab (LGI1/CASPR2/GAD65) detected in serum; bland CSF doesn't rule out these ab. Role of LP? cambridge.org/core/journals/ā¦

š Elianet Fonseca, our team & the Spanish MOGAD Study Group show the performance of the 2023 2023 MOGAD Criteria in Children and Adults With MOG-Antibody Positivity Within and Outside Attacks. neurology.org/doi/10.1212/WNā¦


Happy to have led this work along with amazing researchers in the effort of improving the management of MuSK-MG. More work is needed to find prognostic markers of disease while better understanding the immunobiology of this disease. UniversitĆ di Firenze Azienda Ospedaliero-Universitaria Careggi UniversitĆ Cattolica Nuffield Department of Clinical Neurosciences



neurology.org/doi/10.1212/NX⦠Proud to share Stefano Masciocchi latest work on PLP1 antibodies in demyelinating diseases. PLP1 abs are mainly found in patients with non MS diseases with combined central and peripheral demyelination, but also in rare seronegative NMOSD




#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance Here - in Science Advances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation. science.org/doi/10.1126/sc⦠More below ššæ

Congratulations Mayo Florida AutoImmune Neurology Group Bo Sun John soltys and team for their elegant study delineating breakdown in central and peripheral tolerance in CASPR2 antibody positive encephalitis!


Epstein-Barr virus is a proposed trigger of multiple sclerosis, but the involvement of virus-infected B cells has remained unclear. Luftig Lab & team University of Pittsburgh now identify atypical B cells expressing CXCR3, immune checkpoint molecules, and an EBV-associated pro-inflammatory
