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Our paper Immunity reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n

Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. rdcu.be/dHL6W

Our collaborators develop modeling that helps identify multi-omic #immune #signatures #bioinformatics Leying (Lexi) Guan Steven Kleinstein 🖥 Jeremy Gygi Dr. Anna Konstorum + others pubmed.ncbi.nlm.nih.gov/38603606/

New issue online! Cover depicts work from John Tsang @tsanglab.bsky.social & Matt Mulè &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins cell.com/immunity/issue…

Our latest Immunity paper made cover! Congrats and thanks to Sarah Hopkins for the beautiful art work. Matt Mulè.

Sir Francis Galton on the Central Limit Theorem

There's been amazing coverage of our new paper nature nature.com/articles/s4158… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

#MLCB2024 deadline extended to June 17!!

Imagine a patient at initial presentation with an immune-mediated disease; rather than focusing on tissue/antibody-based diagnosis, you treat based on a test that captures the patient's global immune health. Another great step in that direction from my colleagues @tsanglab

Finally out: Characterizing T cell specific responses to vaccine and infection in HLA-DPB1*04-restricted patients across 4 time points. Thank you Philip Mudd and Ali Ellebedy for inviting me into this amazing data set. Paper: nature.com/articles/s4159…

Check out our recent work describing how vaccination can rewire the baseline immune status of healthy individuals!

1/ We report Immunity that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstr…

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵