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Thursday bonus: RAC9032 F80s, medial cheek. ?BCC excised with 3mm. For thoughts & sharing.

Young adult, upper back. DN-like Melanoma or Nevus With Aberrant PRAME+? IHC at the end is PRAME. (Disclaimer: I did not optimize photos, so thanks for your patience). I am sure I under-tagged many people, but this is open to all.

RAC9032: For indolent malignant appearing dermal spindle/epithelioid, in high UV, I do two panels: S100, Pan-keratin, p63 & CD10. For benign v malignant I do p16, p53 & Ki67. All good suggestions - lymphoid aggregates are a great clue. IHC & my Dx & Disc Comments welcome.

RAC9032: IHC, for thoughts now?

Saturday Querkie: Pennies from Heaven!!! RAC8827.

Collapsing glomerulopathy is characterized by glomerular tuft collapse with overlying epithelial hypertrophy and hyperplasia in Bowman’s space. This pattern of glomerular injury is most commonly seen in African Americans and has been shown to be strongly associated with the

Thursday Classic Quandry: F60s. Cheek. 11 x 5mm, slightly indented, crusted nodule. ?BCC For thoughts & sharing #Dermpath

Cryptococcosis

A novel autoinflammatory syndrome, #VEXAS, has connected previously unrelated inflammatory syndromes and a prototype for a new class of hematoinflammatory diseases. This review summarizes the reported dermatological signs of this disorder. bit.ly/3Nrt3en

Friday Case: RAC9008. F50s Large cyst, shoulder region. For thoughts and opinions #dermpath

MP1: Brain cortex: Nearly every capillary RBC infected by unpigmented parasites (P. falciparum) - rare. Sparse malaria pigment from previous schizogeny. MP1: Liver with haemozoin in sinusoids, lack of parasitised RBC in sinusoids. Anas Nasir Terrie Taylor

🦠#LongCOVID algunas personas después de COVID no pueden hacer ejercicio ➡️Los exámenes de pulmón y corazón están normal ➡️Sus células no pueden usar bien el oxígeno ➡️Se cansan más y sus síntomas empeoran #PESM

❓What is the #diagnosis? A 6-year-old boy presented to our clinic with a patch of #alopecia on his #scalp for 2 weeks. 🔍 LC-OCT imaging revealed #corkscrew #hairs filled with punctiform hyper-reflective structures. Reply with your diagnosis in the comments!

2024 Wk 3 RAC9043: Late 60s. Nasal side wall. 5mm lesion ?LM ?solar lentigo. No tricks. Thoughts & opinions. Last image bx edges #dermpath

The "Eyeliner Sign" in melanoma! While the #EyelinerSign is often linked with SCC in situ/Bowen’s disease or occasionally Paget’s, this case of nevoid (nested) melanoma in situ is showcasing the same distinctive feature. #DermPath #PathTwitter #pathfulness

Hoy 4 de febrero es el DíaMundialContraElCáncer y les recuerdo que: El cáncer cutáneo es el más frecuente de los cánceres mundialmente. (1)

❓What is the #diagnosis? Hint: We report the case of a girl who developed multiple #papules on a hyperpigmented area of her left #face. Histopathological examination revealed epithelial and fusiform melanocytes with cytoplasm and central vesicular nuclei in the #dermis.

2024 Wk13 Thurs: M~70. Longstanding mole lower back, has changed, clinically slightly variegated colour. 4 opinions & sharing #dermpath David Terrano

Merkel cell carcinoma: small metastasis in a lymph node. Very nice cellular contrast on H&E alone. Salt-and-pepper chromatin. #RealLifeDermpath #dermtwitter #dermpath

Con el último informe disponible de Sarampión en México, vemos algunas cosas que siguen preocupando: 1) Son 3,171 casos confirmados. 2) Van 9 defunciones. 3) Hay 20 estados con casos confirmados. 4) Desde 1991 (34 años!!) no teníamos un número tan alto de casos confirmados.