Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory #immunometabolism sciencedirect.com/science/articl…

Very interesting study that shows endogenous itaconate is pro-inflammatory in tissue resident alveolar macrophages. Itaconate derivatives are still anti-inflammatory, which suggests they hold more therapeutic potential #immunometabolism cell.com/cell-metabolis…

RESEARCH | Dylan Duerre, Andrea Galmozzi et al. (UW–Madison): Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which impairs #thermogenesis 🐭🌡️ nature.com/articles/s4225…

RESEARCH | A Tsyben, R Mair, KM Brindle (Cambridge University): The spatial distribution of labelled metabolites in #glioblastoma samples from patients infused with 13C-glucose 🧠 nature.com/articles/s4225…

RESEARCH | Kyle Flickinger, Judith Simcox PhD, Jason R. Cantor et al (Morgridge Institute, Morgridge Metabolism, UW–Madison Biochem) #NADK as an essential factor for supporting dihydrofolate reductase activity and #folate dependent nucleotide synthesis in #Cancer cells nature.com/articles/s4225…

Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline dlvr.it/TLjgl1

New! Online now: Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression dlvr.it/TLmzmD

RESEARCH | T Paulenda, Maxim Artyomov et al. (WUSTL): Itaconate inhibits the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby enhancing type I interferon production 🧫✨ nature.com/articles/s4225…

📢Last two weeks of #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20… Highlights (1/n) The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion nature.com/articles/s4159…

NEWS&VIEWS | T Ramalho & RT Gazzinelli (UMass Chan Medical School, U de Minas Gerais): A surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin to amplify redox signalling and the type I interferon response in macrophages 🧫✨ nature.com/articles/s4225…

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells go.nature.com/3ItTXms

Don't miss your chance to register and send your abstract!

#Throwback METABOLIC MESSENGERS | P Puchalska, Peter Crawford et al Ketone bodies nature.com/articles/s4225…

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction go.nature.com/3H6yuzC

Latest advancements in small molecule analysis selected in collaboration with Bims: Biomed News biomed.news/bims-metlip/20…

🔉Last week's #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlights: I) The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation - nature.com/articles/s4146… II) Polyamines regulate adaptive antitumor

📢Last weeks #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlights: I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabolis…

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Species-specific serine metabolism differentially controls natural killer cell functions go.nature.com/46TOvDv

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction 🔗biorxiv.org/content/10.110… 📦 saezlab.github.io/MetaProViz/ 🧵 Thread