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Hot off the press: Weisel et al (2020) "Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis." Congrats to Flo and the team. nature.com/articles/s4159…

Thanks to Gabriel Victora and Juhee Pae for a great News and Views

Our portfolio company, BlueSphere Bio, hosted a ribbon cutting ceremony to celebrate the opening of its new, state-of-the-art custom lab space. Special thanks to bill peduto, @ACE_Fitzgerald, and Bruce A. Kraus for coming to show support. Congratulations, BlueSphere!

I thought this was particularly telling. Let's hope he's the only face ever that has to occupy this ignominious intersection

Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity cell.com/immunity/fullt…

Check out my Immunology Podcast, just posted by Immunology Podcast . Enjoyed chatting with Brenda and Jason about how basic research can lead to applications. I talk about starting the personalized cancer immunotherapy company BlueSphere Bio with my brother Warren. Mark Shlomchik Lab

The Shlomchik lab, in a group effort led by Dr. Claire Leibler, former postdoctoral fellow, has published their work in Nature Immunology on how TLR9 has both negative and positive regulatory functions in lupus. The links are here: pubmed.ncbi.nlm.nih.gov/36151396/ nature.com/articles/s4159…

Is IL-21R signaling in GC B cells different from naive B cells? How do different combinations of BCR, IL-21R and CD40 signals impact GC B cell fate choice? Differences between IgG and IgM GC B cells? For answers, check out our paper in Science Immunology: science.org/doi/10.1126/sc…

Good things come in pairs! ✌️ Check out these two new Science Immunology articles investigating differentiation and signaling of germinal center #Bcells. 1️⃣ bit.ly/3xxbwsX by Wei Luo, Mark Shlomchik Lab & co. 2️⃣ bit.ly/3xyQzh6 by Di Yu 余迪 & co.

In our latest Journal of Experimental Medicine study, we characterized age-associated B cells (ABCs) in a model of lupus. We found unexpected heterogeneity among ABC subpopulations, identified precursor-product relationships, and showed that reducing ABCs improved renal disease. A 🧵! (1/12)

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice, say Kevin Nickerson @KMNickerson, Mark Shlomchik Mark Shlomchik Mark Shlomchik Lab University of Pittsburgh & colleagues. bit.ly/3ZgTxTw See video summary by Nickerson: youtu.be/YbRb282V6ZI #Autoimmunity

ASCI member Mark Shlomchik Mark Shlomchik Lab University of Pittsburgh in JCI insight: Severe lupus in TLR9- deficient mice requires B cell-specific TLR7: buff.ly/3YX65jS #Immunology

Mark Shlomchik Lab Mark Shlomchik Happy 30th anniversary! Thanks for hosting a phenomenal symposium. No better way to celebrate!

Check out the clip below to learn from the career advice given by last Wednesdays #globalimmuno speaker speaker Dr. Mark Shlomchik Full talk is available in “Global Immunotalks” YouTube Channel youtu.be/zm7RVMOLk_E

Global Immunotalks Mark Shlomchik 2- which model are you using? what is triggering lupus in it? Is it known WHY one of the TLRs is protective and the other pathologic? Only the intracellular signaling? Different recognition of different nucleotides (from… self? Infections?) may have a role? THANSKS!!!

I'm thrilled that the very first paper from my lab, also my first senior author paper, is now online Cell Reports. cell.com/cell-reports/f…

Check out the N&V in Nature Immunology by Inaki Sanz about Rebecca Elsner Mark Shlomchik Lab's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg. nature.com/articles/s4159…