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Imagine a dataset where it's the whole of the AlphaFold Database but you can pull-out the domain-like structures avoiding random spaghetti, or get all the domain-domain interactions, or check whether domains match a known structural super-family. That's TED:

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2

GPUs are *fast* at aligning protein sequences (and profiles!). 178x faster than JackHMMER! In ColabFold, 23x faster end-to-end compared to AlphaFold2 reaching the same accuracy! You get immediate speedups for all methods leveraging MSAs, from DCA, to PoET, and even AlphaFold3!

Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on

What a heartening and inspiring thing to come across at the end of my walk to a meeting University of Oxford.

Excited to share our latest on RNA polymerase I termination. Fantastic collaboration with Elisabeth Petfalski Marie-Luise Winz David Tollervey online today in Cell Reports cell.com/cell-reports/f… #DNA #RNA Institute of Biochemistry and Biophysics PAS Read next tweets to check out our key findings

Thèse en glycochimie disponible dans notre équipe @ICOA_UMR7311 Université d'Orléans CNRS Chimie ANR - Agence nationale de la recherche Si vous êtes intéressés, merci de postuler via le portail ADUM à cette adresse : collegedoctoral-cvl.fr/as/ed/voirprop…

PhD position with our neighbours - a friendly team working on mRNA: abg.asso.fr/fr/candidatOff…

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…

My brilliant friend Martin Lukačišin started his own systems biology lab and is looking for a PhD student or postdoc. Highly recommended!

Our recent article in Journal of Molecular Biology explores how Post-Translational Modifications (PTMs) orchestrate the repair of trapped Topoisomerase-induced DNA breaks via TDP1 and TDP2. sciencedirect.com/.../pii/S00222… Indian Association for the Cultivation of Science DSTIndia ICMR Department of Biotechnology