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IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation biorxiv.org/content/10.110…

🚨 Great alternatives to BioRender are now available!! 📢 NIAID News offers a collection of public figures and icons for everyone to use. Check it out at bioart.niaid.nih.gov

The tumor microenvironment of SCLC is often "immune cold" (due to low T cell infiltration & high immune suppression), & frequently shows high levels of DNA damage response. Despite these complexities, new clinical targets are now demonstrating promising activity: DLL3, B7H3,

First of a series of papers from the @NCIHTAN is out in nature this morning. Tumour evolution and microenvironment interactions in 2D and 3D space nature.com/articles/s4158…

Huge congratulations to Karuna Ganesh for this important study out in nature Progressive plasticity during colorectal cancer metastasis nature.com/articles/s4158… Many orthogonal patient-derived models, and an important lesson here for all: "The non-canonical states that we

Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. Jonathan Kipnis 💔🎗️ nature.com/articles/s4158…

Because ONE spatial profiling technology is not enough! New paper by Nikhil Wagle, MD (he/him) in Nature Medicine A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features nature.com/articles/s4159… Dissociated single

Thrilled to share our paper published in nature, where we uncover a new process of tumor initiation through a polyclonal-to-monoclonal transition at the @precancerous stage. So proud of my fantastic team (led by Zhaolian Lu ) and incredible collaborators! nature.com/articles/s4158…

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in nature nature.com/articles/s4158…

Enhancing transcription–replication conflict targets ecDNA-positive cancers | Nature nature.com/articles/s4158…

One of the major challenges in human genomics is the functional assessment of variants. Base and prime #CRISPR genome editing is making a big difference for meeting that challenge, as exemplified in this new report Nature Biotechnology nature.com/articles/s4158… Randall Platt

#CARTcells for #DIPG #DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief. “There’s a

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas | Nature nature.com/articles/s4158…

I’m excited to share our latest study in @nature on this novel compound called Gliocidin, that targets glioblastoma (#GBM), the most malignant brain tumor. #drugdiscovery #cancer #cancermetabolism GSK Graduate School Memorial Sloan Kettering Cancer Center nature.com/articles/s4158…

Our work reveals that as IDH mutant gliomas progress, their cell states and key drivers change. nature.com/articles/s4301…

Incredible team effort on this translational project - just in time for SNO! Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses academic.oup.com/neuro-oncology…

Check out our latest paper integrating genomic and functional precision medicine to identify therapeutic vulnerabilities in glioblastoma nature.com/articles/s4146…

Finally out in Science Magazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific