Just out in JAMA Network Open, we analyze use of terms that minimize toxicity in myeloma trials. Thanks to a stellar team led by Mimi Najjar, MD, with Raj Chakraborty Eddie Cliff David Steensma, MD Aaron Goodman - “Papa Heme” Samer Al Hadidi, MD,MS,FACP Kate tinyurl.com/3hfm28sw #mmsm 🧵1/

Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1

Meet the longest lasting project of the lab⏳ 🦴 marrow fat cells provide local fuel for hematopoietic stem cells after MI 🔥 rdcu.be/dsN4e Very happy that it is now out in Nature Cardiovascular Research ❤️ Thank you fellows and collaborators for hanging in there on this journey!

#ASH23 Excellent talk from Michael Savona describing Alex Silver wonderful PhD work which delineates differences in the biology and clinical outcomes between distinct DNMT3A variants. Going to be hard to justify lumping all DNMT3A mutations as one entity in CHIP going forward

Matt Jenkins from Ferrell Lab with the most popular poster describing his work on TET2 and monocyte inflammation in CH. #ASH23

⭐️THRILLED to host this meeting w/ my good friend Dr. Cathy Eng in beautiful Nashville. Join us as we have the LEADING thought leaders discuss the latest data including a special appearance by the Oncology Brothers Register here👇 web.cvent.com/event/c61fd6dd… Dr. Cathy Eng David R. Spigel, MD, FASCO

It was great to see everyone who attended our MPN-MDS US Focus Meeting last week! Our 5th annual meeting was better than ever with great presentations and debates all moving forward the future of treatment options for patients. Thank you to the wonderful co-chairs,

🔥 Tune in to our new episode on maintenance therapy in #MultipleMyeloma with Hira Mian & Manni Mohyuddin ! We discuss a wide range of RCTs from CALGB to FORTE, ideal endpoints for maintenance trials, and role of MRD! tinyurl.com/4mtjyz6m Here is clip on Dara maint. in CASSIOPEIA!

Informative paper in Blood Journal re achievement of CRh with targeted therapies in AML! ashpublications.org/blood/article/…

It's out! Jackie Bader led our new The Mark Foundation for Cancer Research Endeavor team study showing obesity promotes PD-1 on macrophages to suppress anti-tumor immunity but sensitize to checkpoint therapy--a new mechanism of the cancer "obesity paradox" VUMC_VCI Vanderbilt-Ingram Cancer Center nature.com/articles/s4158…

Our latest research on the Risk of Incident Cytopenia in Clonal Hematopoiesis is live on medRxiv! We leveraged data from 3 biobanks AllofUsResearch UK Biobank & BioVU (Vanderbilt Health biobank) to investigate how #CHIP drives cytopenia & subsequent progression to myeloid

🎉Excited to present our latest work out today nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN? nature.com/articles/s4158…

2024 year in review out now highlighting the three most impactful clinical trials in colorectal cancer this past year: nature.com/articles/s4157…

Our amazing @VUMC_Cancer fellow Margaret Wheless, MD is presenting her data at the upcoming poster session at 11:30! Don’t miss it! #GI25 Dr. Cathy Eng Dr. jordan berlin Kathy Walsh, MD, MAEd

#ReviewSeries: Villaume and Savona review the current knowledge of inflammaging and aging of the hematopoietic system connecting them with the progression from CHIP to myelodysplastic syndromes. haematologica.org/article/view/h…

Management of Systemic Mastocytosis with Dr. Daniel DeAngelo youtu.be/XcfbCV-_-1g?si…

With the disappointing announcement today by AbbVie of the negative result of the VERONA venetoclax/azacitidine trial, that brings the tally to (by my count) 17 consecutive negative randomized drug trials in higher-risk #MDSsm. This is a slide I made summarizing them./1

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity dlvr.it/TMMZfb

Using a unique cohort of 10k doubly sequenced people in Vanderbilt University Medical Center's BioVU, Alex Bick, Yash Pershad, and I investigated how well #WGS data really works for detecting #CHIP. medrxiv.org/content/10.110…. Thread below! 1/n

Congratulations to Anthony Daniyan & team from Memorial Sloan Kettering Cancer Center on publication of the initial data from AML patients treated with IL-18 secreting CD371 CAR T cells @MSK. ashpublications.org/blood/article-… 3 / 5 patients experienced MRD-negative morphologic leukemia free state.