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Congratulations to winning the 2024 Eppendorf Young Investigator award Plaschka Lab! Clemens is not only a brilliant scientist with a clear vision for his lab, he is also an incredibly supportive mentor and great supervisor. Well deserved!

We previously showed that a coincident FM-FIB-SEM can be turned into a 4D-STEM system for in situ thickness determination (edu.nl/8xh97). Daan applied this to cryogenic samples, allowing automated, thickness-controlled milling of frozen-hydrated lamella from cells.

Thank you Sasha and Rui for highlighting our work on the initiation of spliceosome disassembly! nature.com/articles/d4158…

Just released in #EMDB & Protein Data Bank and published in Nature Magazine: The composite map of C. elegans Intron Lariat Spliceosome (ILS’) primed for disassembly @ 2.9 Å! The focused maps used to construct this volume are well-linked to this entry.

Science in Shorts Spotlight: Laura de Rooij @PhilDexheimer explain the research on rejuvenating endothelial cells lining blood vessels, which age and cause cardiovascular issues. go.nature.com/3SH7KYR

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Come and explore the mechanisms of gene expression with us! We are hiring two postdocs in cryo-EM and - with Francisco Balzarotti - in super-resolution microscopy. 👉imp.ac.at/career/open-po… 👉imp.ac.at/career/open-po…

🚨Hiring a Research Technician!🚨 Join our lab to study mobile DNA and its impact on biology and genome engineering! 🌟 MSc. in Molecular Biology, Biochemistry or related field required. PhD highly desired. 🌟 70% Research 30% Admin 🌍 Max Perutz Labs Vienna, Vienna BioCenter #Austria

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! biorxiv.org/content/10.110… 🧵 (1/7)

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/sh… (1/6)🧵

I'm extremely excited to announce that I've been promoted to Senior Group Leader (with tenure) at the IMP. A BIG thank you to every lab member for your fantastic work over the years, and to our wonderful colleagues, mentors, and friends for their continued support.

In 2019-2021 Brent Nannenga and I put together this methods in cryoem book. It was a lot of work. It sells for 120$ and chapter downloads are 35$. The publisher informed us that they had 78,000 downloads so far. Thats several million dollars profit for them... We got nothing 😳