Beautiful thread on how AlphaFold3 can be used to confidently model CC-NLR resistosomes! Turns out oleic acids can be used as a substitute for membranes to enable better modelling of N-terminal pores 😮! Check it out! 👇🧵

I am *beyond thrilled* to have the work from my PhD finally out!! 💫 We found that MLA3, a plant immune receptor, mimics a virulence target of Magnaporthe oryzae to set a trap for this fungus and trigger disease resistance. How cool is that?! 🤓 🧵1/15 biorxiv.org/content/10.110…

A sharp discovery | Science science.org/doi/10.1126/sc…

A two-component signature determines which rust fungi secreted proteins are translocated into the cells of the host plant biorxiv.org/content/10.110…

How to escape an alligator death roll [🎞️ Zack D. Films]

On the response of elongating ribosomes to forces opposing translocation: Biophysical Journal cell.com/biophysj/fullt…

🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…

சரியான முடிவுகள் எடுப்பதில் எனக்கு நம்பிக்கை இல்லை.. நான் முடிவுகளை எடுத்த பின் அதை சரியாக்குவேன் - Ratan TATA Rip sir...😭😭😭😭😭😭😭 #RatanTata

A versatile protocol for purifying recombinant proteins from Nicotiana benthamiana for structural studies biorxiv.org/content/10.110…

Reliable reconstruction of cricket song from biophysical models and preserved specimens biorxiv.org/content/10.110…

#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? M. Selvaraj Mauricio Contreras Sophien Kamoun &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU

Structure determinants of DANGEROUS MIX 3, an alpha/beta hydrolase, for triggering NLR-mediated genetic incompatibility in plants biorxiv.org/cgi/content/sh… #biorxiv_plants

A trade-off between investment in molecular defense repertoires and growth in plants | Science science.org/doi/10.1126/sc…

AI. பயமாகத்தான் இருக்கிறது.

I just published 2024 the year in review Let’s review the year through our team’s publications, blogs and other contributions. link.medium.com/UJfDrAopxPb

This brave guy in Florida came up with a pretty clever way to deal with an alligator!

Better that PlayStation/ Xbox 🎮😮‍💨🤣🤣🤣

Wheat never fails to surprise us—like a CNL that assembles just like a TNL! biorxiv.org/content/10.110…

Please read here about a plant disease resistance protein that makes an octameric resistosome. We describe about its identification, architecture, action and assembly. Congrats to all involved. Guanghao Guo, He Zhao He Zhao Jonathan D G Jones Sophien Kamoun The Sainsbury Laboratory 👇

First a pentamer, then a hexamer… now an octamer! The riddle of the enigmatic CCG10-NLR immune receptor family cracked open 🔥 Congrats Guanghao Guanghao Guo He Zhang He Zhao Selva M. Selvaraj et al. #NLRbiology #plantsci #immunology