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Congratulations to the MacMillan Group for their latest, just out in nature: “Unlocking carbene reactivity by metallaphotoredox a-elimination.” Great work by Ben, Nathan, Dave and colleagues at Janssen: bit.ly/4ebrtsH

For any cyclopropane fans – ICYMI, see our latest report in nature. Using one-electron logic, iron carbenes can be made from simple reagents like lactic acid, trifluoroethanol or alanine. Congrats to Ben, Nate and our awesome collaborators at Janssen! nature.com/articles/s4158…

Congratulations to our German postdoc Johannes Grosskopf (Johannes Großkopf) who has been awarded the 2024 Albert-Weller award by the German Chemical Society GDCh Division of Photochemistry for his outstanding contributions to photochemistry as a young academic. Well done, Johannes!

Farewell, Vittorio and Ryan! It's been a pleasure having you both in the lab, sharing your knowledge and passion for chemistry. Wishing you all the best in your next adventure. You'll be missed! #SafeTravels

Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean! nature.com/articles/s4158…

It was a pleasure for the MacMillan Group to host high school organic chemistry students from the Trevor Day School in NYC today. Thanks to Andria Pace Princeton Women in Chemistry, Will Lyon, and David MacMillan for giving them an idea of what we do here at Frick Lab!

Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! Sean Huth Jacob Geri James Oakley

Check out our latest work in JACS— Access to a nucleophilic Fe(I) complex allows for activation of 1° electrophiles via an SN2-type mechanism. Subsequent SH2 bond formation enables all-carbon quaternary centers. Congrats Andria, Felix, Wei, and Marissa! pubs.acs.org/doi/full/10.10…

Nothing like a little holiday cheer in the lab! Our chemistry department got a surprise visit from therapy dogs today—bringing smiles, tail wags, and a much-needed break from the bench. 🐾✨ #LabLife #HolidayCheer #TherapyDogs #ScienceAndSmiles

Parallel Proteomic & Transcriptomic Microenvironment Mapping (μMap) of Nuclear Condensates in Living Cells Journal of the American Chemical Society David MacMillan MacMillan Group Princeton Chemistry #Proteomic #Transcriptomic #Mapping #Nuclear #Condensates #LivingCells pubs.acs.org/doi/10.1021/ja…

Check out this latest work in JACS from Steve, Roderick, Niels, Brandon, Philip, and Iakovos! 🎄 pubs.acs.org/doi/10.1021/ja…

Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain! pubs.acs.org/doi/10.1021/ja…

Spring into some great seminars from POCC ! Next week's installment is Princeton Chemistry very own David MacMillan for our Allan Day award lecture. Prof, MacMillan will be discussing research from MacMillan Group including organocatalysis, photoredox catalysis, and microenvironment

Want to selectively couple two radicals?... You're in luck! Check out our newest work in Nature where we use dynamic orbital selection to unlock alkylation of native aryl C–H bonds. Congrats to Johannes Großkopf, Charlene, Robert, and Alex! Read more at: nature.com/articles/s4158…

Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat! Give it a read here: cell.com/chem/abstract/…

Thrilled to announce that Brandon Bloomer of the MacMillan Group has been named a 2025 Beckman Foundation Postdoctoral Fellow in the chemical sciences, one of just 14 across the country. Congratulations, Brandon! Announcement here: bit.ly/3S1KAvr

Alcohols + aryl acids = C(sp3)–C(sp2) bonds! In collaboration with The Long Group & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan! pubs.acs.org/doi/10.1021/ja…

‘Tis the season! Here, Noah Bissonnette of the MacMillan Group during his dissertation defense, and being introduced by adviser David MacMillan. Best of luck to all graduate students defending this spring! You are our future.

With thanks to these esteemed early-career researchers Steve, Sijbren, Alex, Kristina, and Erik who presented at yesterday’s Princeton Catalysis Initiative Symposium opener. Well done, all.

Old tissue, new tricks?? We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples. 📃: doi.org/10.1021/jacs.5…