🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases biorxiv.org/cgi/content/sh… #bioRxiv

Today in bioRxiv, we introduce Click Editing - which combines DNA-dependent polymerases, HUH endonucleases, and RNA-programmable nickases for versatile human genome editing without double-strand breaks. Co-led with Joana Ferreira da Silva 🤝🧬 (1/15) biorxiv.org/content/10.110…

Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with Connor Tou. A 🧵 (1/14): biorxiv.org/content/10.110…

We’re excited to share our work developing a new gene editing approach that we’re calling #clickediting 🖱️✴️🧬. Click editors (CEs) utilize DNA-dependent polymerases to write bespoke edits into the genome. biorxiv.org/content/10.110… CGM at MGH MassGeneral News @MGH_RI Harvard Medical School

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

I'm a little late to the party, but glad to share that our manuscript describing click editing has been published in Nature Biotechnology. An amazing team effort led by Joana Ferreira da Silva Connor Tou & others. CGM at MGH @MGH_RI Harvard Medical School #clickediting 🧬 nature.com/articles/s4158…

In a new Nature Biotechnology study, researchers from CGM at MGH and colleagues investigated programmable genome writing via click editing with DNA polymerases and HUH endonucleases. Read more: massgeneral.org/news/research-… Ben Kleinstiver Joana Ferreira da Silva Connor Tou

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base

Investigating Gene Expression Noise Reduction by MicroRNAs and MiRISC Reinforcement by Self-Feedback Regulation of mRNA Degradation biorxiv.org/content/10.110… #biorxiv_sysbio

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ Rachel Silverstein CGM at MGH @MGH_RI MassGeneral News Harvard Medical School nature.com/articles/s4158…