Time for a celebration! We are very happy and proud that Oncode Institute will continue for another 5 years! oncode.nl/news/follow-up… Image by Jonne Raaijmakers, Rene Medema Lab, The Netherlands Cancer Institute

Great initiative by Utrecht University. For trips < 700km or < 8 hours, travel by train is the norm OR digital alternative if trip is non-essential. This new policy comes with a handy tool to check travel times and CO2 emission: uu-rightontrack.nl/en

Proud of this work we did in collab with Enrico Mastrobattista - With help of many of the lab, and a starring role of Pkerkhof who even came back from retirement to help finish experiments! 🤩🥰

Workshop on Wnt signaling as a drug target in human disease. March 17th, 2023 in Heidelberg (and virtual). For online participation, please register here: us06web.zoom.us/webinar/regist… Program: sfb1324.de/event/wnt-work… #Wnt @sfb1324 DKFZ Uni Heidelberg EMBL DFG public | @[email protected] Please RT

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Looking forward! 👇

It was nice catching up with old and new colleagues/friends and all the new advancements in the Wnt signalling field. Exciting times ahead! A big thank you to the (vice) chairs for organising this GRC #Wnt2023 meeting 👏👏 Stephane Angers Mariann Bienz Madelon Maurice Ken Cadigan

Job Alert📢📢 We are recruiting postdocs in Protein Biochemistry bit.ly/45vrx1A & Cell Biology bit.ly/45ijcOX to join our lab Department of Biochemistry at Oxford University. Join us to tackle the next big challenges in the Wnt signalling field in a fun, collaborative & supportive environment!

Van der Krift et al. report on the mechanistic characterization of a novel, lipophilic antifolate that suppresses the growth of FPGS-deficient cells that are linked to methotrexate resistance and relapse in cancer patients Madelon Maurice @UMCU_CMM bit.ly/3quDHsL

New group leader position Cell Engineering Faculty of Science, Utrecht University Utrecht University Check out vacancy link for more details👇👇👇Apply now! uu.nl/en/organisatio…

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Very pleased to announce the 2024 EMBO FEBS Lecture Course on signal transduction and cancer! 📍 Spetses (GRC) 🗓 August 18-26, 2024 Expect great speakers, motivating discussions and ☀️ Registration is open. Feel free to forward to whoever you think might be interested!

Had a blast at the TPD Keystone meeting! With a starring role of @JessieKroonen presenting how we use our #SureTACs technology to degrade PD-L1 🤩 @UMCU_CMM Laigo Bio #KSProteindeg24 #KSProximityTx24

Registration for the #EMBO #FEBS Spetses 2024 Lecture course on Signal Transduction in Cancer is open! PhD students and postdocs check out the exciting program with lots of science, fun and ☀️, application deadline April 1 👇 meetings.embo.org/event/24-signa…

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations Madelon Maurice Jeroen Bugter @UMCU_CMM bit.ly/3WcTol5

Our paper exploring the different mechanism and selectivity of Frizzled regulation by the presumed paralog tumor suppressor genes RNF43 and ZNRF3 has been published! No time to read? I tried to summarize the main message in a one minute video 👇

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations Madelon Maurice Jeroen Bugter @UMCU_CMM hubs.la/Q02FyGnP0

This year, on June 5th, I am taking on the challenge of climbing Alpe d'Huez multiple times to contribute to the fight against cancer. Will you support me? Every contribution, big or small, makes a difference!! opgevenisgeenoptie.nl/fundraisers/ma…