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Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression biorxiv.org/cgi/content/sh… #bioRxiv

Happy to share the pre-print of our recent findings! Check out how breast cancer cells exploit altered metabolism to achieve histone lactylation-dependent upregulation of oncogenic transcription factor c-Myc! Sanjeev Shukla ERPLab@IISERB SommyaSinha #CancerResearch #breastcancer

PROUD 🇮🇳

This is what dreams are made of! After 5.5 years of sheer hardwork, finally earned doctorate degree 🎓 Yours truly is officially Dr. Madhura Pandkar now! Immensely thankful to Sanjeev Shukla ERPLab@IISERB IISER Bhopal

100 Influential Women in Oncology: Key Opinion Leaders to follow on Social Media in 2023: Part 3 🇪🇺🇨🇾🇺🇸🇬🇧🇨🇦🇰🇪 oncodaily.com/positive/9118.… On August 26th, OncoDaily began featuring '100 Influential Women in Oncology: Key Opinion Leaders to Follow on Social Media in 2023.' As we

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Is there anything which altered metabolism can't do?! Find out all about the fascinating mechanism by which cellular redox status shapes the cancer epigenome via oxidizing histone H3.1 and replacing it with histone H3.3! #CancerResearch #metabolism #breastcancer #Metastasis

Histone oxidation-mediated gene regulation is here to stay!

What a fun-filled day to discuss the wants and needs of redox epigenetics! Thank you Promega Corporation for hosting the Bonini lab at the beautiful Madison headquarters.

Had a fun time working on this review alongside amazing collaborators! Check out our recent review out now in Trends in Cancer!

Treatment strategies combining standard treatments and #epigenetic modulators seem to be more effective than the standard of care for the management of metabolically defined cancers, per findings from Lurie Cancer Center’s @MarceloBonini8 in Trends in Cancer. sciencedirect.com/science/articl…

Amazing!

Final contribution from my PhD journey is published! The reach and impact of epigenetic mechanisms in modulating cancer outcomes knows no bounds! Find out all about interplay between epigenetics and alternative splicing in our review, out now in Biochemical Journal

Should probably watch Batman Begins again to check which all instruments Lucius Fox used that ultimately saved Gotham 🤯🥲

This review from Pandkar and Shukla illuminates new perspectives of epigenetics and alternative splicing in cancer. Read the full review now! doi.org/10.1042/BCJ202…

My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik Bercin K Cenik did it and here it is cell.com/molecular-cell… Not

Wonders of CTCF in cancer! Congratulations to all the authors on this amazing study!

Exciting PhD opportunity! Join our lab ERPLab@IISERB (sshuklagroup.iiserb.ac.in) to explore the fascinating interplay of epigenetics & alternative splicing in cancer. Dive into cutting-edge research! Apply now: phdadmission.iiserb.ac.in #PhD #Cancer #Epigenetics #AlternativeSplicing