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Two drugs are better than one—blocking drug action in the periphery while maintaining CNS pharmacology (mTOR, Lrrk2 and Her2). #Glioblastoma Ziyang Zhang and Waweisslab.UCSF.edu UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI College of Chemistry michaeljfox.org nature.com/articles/s4158…

Really happy to see it out. The first structural corrector for genetic cardiomyopathy. Stay tuned for more stories.

1/ Grant-writing tips. This #tweetorial mainly applies to NIH grants (particularly R01s) but some stuff may be applicable to other types of grants and funding agencies. Based on my experience writing grants for 20 yrs +lots of cringe-worthy missteps and rejections along the way!

💯 '‘the rule of two’: At least two chemical probes (either orthogonal target-engaging probes, and/or a pair of a chemical probe and matched target-inactive compound) to be employed at recommended concentrations in every study.' nature.com/articles/s4146…

Such a huge loss :( الله يرحمه و يحسن اليه cen.acs.org/people/obituar… via C&EN (Chemical & Engineering News)

Excited to share our recent work where we identify two FDA-approved drugs that induce heart regeneration in small and large animals. Outstanding work by Mahmoud Salama Ahmed and Nguyen Ngoc Uyen Nhi! Bringing regenerative therapies a step closer to the clinic rdcu.be/dANtR

The long awaiting story is finally out :) Thank you Nguyen Ngoc Uyen Nhi for partnering to finish this marathon. Thank you Hesham Sadek for believing in this dream to deliver the first small molecules for cardiac regeneration to the clinic. nature.com/articles/s4416…

What if you could carve your own pathway to a rewarding career in pharmacy? At TTUHSC Jerry H. Hodge School of Pharmacy, we are excited to introduce the Pioneer Pathway, a groundbreaking flexible approach to high-quality clinical pharmacy education that will start in Fall 2024. dailydose.ttuhsc.edu/2024/march/sop…

We are seeking to fill two postdoctoral fellows in synthetic medicinal chemistry. Projects aim to develop novel opioid modulators using structure-based design in collaboration with the Jay Mclaughlin lab at UF and Brian Kobilka lab at Stanford. Email me [email protected]

We're still looking for a motivated postdoc to help us investigate the role of bacterial biofilms in IBD. Pls RT Apply through this link: apps.ualberta.ca/careers/postin…

Congrats to Stanford CVI researchers & Greenstone Biosciences #computationalscientists for identifying #artesunate as potent #antifibrotic drug for cardiac fibrosis, published in Cell. Free link: authors.elsevier.com/a/1jxLPL7PXqSAi Stanford Medicine Stanford Department of Medicine Sarafan ChEM-H UAZ Medicine - Phoenix

Excited to share the latest collaboration spearheaded by Olaf Bergmann Jonas Frisén Stavros George Drakos this work started with our Leducq consortium 6 years ago showing that LVAD responders have a higher rate of new myocytes formation. ahajournals.org/doi/10.1161/CI…

Mahmoud Salama Ahmed spearheaded the computational screen which identified the FDA approved drugs. Together with Ping Wang and Nhi Nguyen, they combined medicinal chemistry, X-ray crystallography, as well as cell and animal models to identify risedronate as a structural and

A cannabinoid bitopic, biased and peripheral agonist analgesic with limited tolerance and tetrad in Nature. Work led by Vipin Rangari with Rob Gereau Dror Lab kaavya Krishna Kumar Center for Clinical Pharmacology WashU Medicine Anesthesiology A short thread nature.com/articles/s4158…

Cannabinoid targets hidden pocket for safer pain relief nature.com/articles/d4157… Highlight of our cannabinoid paper by Nature reviews drug discovery Rob Gereau Vipin Rangari Dror Lab Amynah Pradhan Rich Slivicki Center for Clinical Pharmacology Evan O’Brien WashU Medicine WashU Medicine Anesthesiology Research