OUT NOW: The Vibrio cholerae CBASS phage defense system modulates resistance and killing by antifolate antibiotics BrochadoLab @SuBrenz Universität Würzburg #UniWürzburg Controlling Microbes to Fight Infections nature.com/articles/s4156…

How do we get new antibiotics that work in real life? In this article our NCCR AntiResist consortium argues that in vitro models mimicking relevant patient-like conditions will be a crucial tool to find the right molecules (or phages 😉). 🔥👇🏼

To get the new year off to a good start, I'm more than happy to announce that I'm joining @FredoLeRoux in Montreal as a post-doc, to work on some super exciting projects !

What a start for the PGB lab in 2024 with yet another integron story! This time we uncover how toxin-antitoxin cassettes have shaped the evolution of chromosomal integrons, turning them into giant genetic libraries for fast "à la carte" adaptation! tiny.cc/xwh0wz

Excited to share the preprint of my main thesis work on BioRxiv. Immense grateful to my former supervisor @labXC for ongoing support, and to all co-authors for their indispensable contributions Julie P, Violette Morales with @POLARD_Lab, @FannyMzzro and @epcrocha

A phage that can kill dormant, antibiotic-tolerant bacteria Enea Maffei Alexander Harms #phages #bacteria #PhageTherapy #microbiology #Pseudomonas nature.com/articles/s4146…

💥💥 Thrilled to share this last PrePrint, for those interested in bacterial genome biology, plasmids and secondary chromosomes. A Big thanks to all the authors.

It’s online! Follow up study from my main PhD project where we find how point mutation in the integrase and genomic rearrangements buffer the toxicity associated with cassette excision in the Superintegron in V. cholerae over just a few generations! journals.plos.org/plosgenetics/a…

Very excited to share our latest publication (first of my group in IAME Research Center) in Cell Host & Microbe ! We quantified E. coli cell division over the course of UTI. (1/7) cell.com/cell-host-micr…

Please repost: Positions for: Project coordinator, Platform manager, Lab manager, Postdoc, Ph.D. for 4-year $21 million project to develop an integrated, active learning-based antibiotic discovery pipeline. See jobs at brunlab.com/research/antib…. Email [email protected]

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages. 🦠💊 by Dieudonné Zongo, Isabelle Rosinski-Chupin and Philippe Glaser nature.com/articles/s4146…

Phage predation accelerates the spread of plasmid-encoded antibiotic resistance | Nature Communications nature.com/articles/s4146…

Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the Didier Mazel lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) doi.org/10.1101/2024.0…

Our paper about integrons and their fascinating content is on biorXiv🤩Go check out Eloi's thread for a sneak peek of what these big fellas are capable of !

Check the last piece of work from the lab!!

Our last contribution to the technology arsenal for Vibrio cholerae by Kevin Debatisse Loot Céline bmcgenomics.biomedcentral.com/articles/10.11…

📅 Registrations are now open for the MOOC “Resistance to Antibacterial Agents”! 👉 Enroll Now: bit.ly/4fzYwqV 🌍 It's World Antimicrobial Resistance (AMR) Awareness Week! 💊 #WAAW #AntibioticResistance #AMR #OneHealth #PublicHealth #GlobalHealth #Antibiotics

Generalists in a Specialist World: Vibrio-Phages with Broad Host Range biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in eLife - the journal ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…