🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Very happy to announce that our last woman standing in Dresden successfully defended her PhD! Congratulations Dr. Kristyna Judasova!!!🥳🥳🥳

Posting this for my The ICR colleague and friend Max Douglas - Postdoc opportunity available in his lab - highly recommended for anyone interested in telomeres, biochemistry & structural biology. Great lab and PI! jobs.icr.ac.uk/vacancies/309/…

Good things come to those who are patient ... started in Dresden Biotechnology Center (BIOTEC) of TU Dresden - finished in London The ICR: Our study how ROS promotes proliferation via CDK2 oxidation was just published in Developmental Cell! :-) doi.org/10.1016/j.devc…

📢 Hot off the press 📢 🧬 Ever wonder why some DNA sequences are difficult to replicate? Using reconstituted replisomes we revealed that structure-forming repeats induce robust replication stalling and uncovered structure-specific recovery mechanisms: nature.com/articles/s4146…

📢 NEWS: ICR scientists (Mansfeld Lab) have discovered how naturally occurring, unstable molecules, known as free radicals, can directly regulate a key protein for cell division called CDK2, opening up a potential new way to target #Cancer 👇 icr.ac.uk/news-features/…

Our article on a ROS-dependent regulation of CDK2 (doi.org/10.1016/j.devc…) has just been recommended on @FacultyOpinions facultyopinions.com/article/742227… Thanks verybody Mansfeld Lab & Biotechnology Center (BIOTEC) of TU Dresden & The ICR to make this a worthwile and exciting endeavour.

The Elisa Nerli strikes again! Deterministic and probabilistic fate decisions exist in the same retinal lineage! A tour de force and amazing team effort led and guided by Elisa. She will discuss in more detail, I go on conference and vacation :-). biorxiv.org/content/10.110…

Professor Chris Bakal's lab (@BakalLabICR) show that #Melanoma #SkinCancer cells harness ARHGEF9 - a gene usually used by growing nerves - to drill through surrounding tissues and escape from their immediate area. Read more: icr.ac.uk/news-archive/s…

If you're interested in telomeres and DNA replication, check out this amazing postdoc opportunity in Max Douglas's lab ! linkedin.com/posts/max-doug…

The Mansfeld Lab just returned from the EMBO “Thiol in oxidation in biology” meeting. Super exciting and at a wonderful place. And Julia Vorhauser won the POSTERPRIZE. Thanks to Bruce Morgan, Haike Antelmann and Dana Reichmann for organising one of the best workshops this year.

Interesting bioRxiv by the group of Ben Cravatt Scripps Research with the group of David R. Liu. They use base-editing to assign essentiality to >10,000 cysteines in cancer cell lines. Full post on Mastodon (@[email protected]) @[email protected]. doi.org/10.1101/2022.1…

Many congratulations to Alex Radzishueskaya in our Division who has been awarded an ERC Starting Grant!

I am thrilled and honoured to be one of the #ERCStG recipients! So grateful to European Research Council (ERC), my mentors, colleagues at the @ICR and my family. We will explore the roles of histone acetylation in cancer and will be recruiting soon. erc.europa.eu/news-events/ne…

How does polymerisation activate the ADP-ribosyltransferase tankyrase? We are a few steps closer to the answer: rdcu.be/c0hLX. Congratulations to the team, and thank you to our funders, especially Science and Innovation at Cancer Research UK Wellcome The ICR The Lister Institute of Preventive Medicine!

An extraordinary paper showing an unexpected redox role for BCAT1 in accurate chromosome segregation. There is clearly something important about how redox changes modulate the cell cycle, especially in mitosis. doi.org/10.1016/j.celr…

We have several postdoc openings! tu-dresden.de/cmcb/biotec/fo… Our interdisciplinary group works on the #Genomics of #DNAdamage and #Mutagenesis using #ComputationalBiology, #MachineLearning and #AI. (details in following tweets)

UK REDOX NETWORK Meeting Session 2: Helena Cocheme (Imperial College) introduces Joerg Mansfeld (Institute of Cancer Research) (intranet.sfrr-europe.org/documents/UKRe…; Europe-SFRR SFRR-Australasia SFRBM Helena Cocheme Julia Vorhauser

The lab’s first pre-print is out! ‘A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment’ biorxiv.org/content/10.110…

Have you ever wondered what H2O2 does in your cells? We are looking a highly motivated #Postdoc to investigate #Redox regulation of #DNAReplication and #DNADamage repair. Our lab is based at the ICR in Chelsea, London, UK. Please apply here: rb.gy/7ddtmh #mansfeldlab

UK REDOX NETWORK 2025 Meeting at Institute of Cancer Research, London SW7 3RP28 April 2025. Excellent programme coordinated by Olena Rudyk (KCL) and Joerg Mansfeld (ICR). Europe-SFRR Cardiovascular and Metabolic Medicine & Sciences Elsevier Biomedchem