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Proud to present our findings in Cell about neuronal STING as integrator of inflammatory and glutamate signals in #multiplesclerosis. Great work by Marcel Seungsu Woo , Christina Mayer , INIMS collaborators Merkler lab The Conrad Lab Markus Glatzel cell.com/cell/fulltext/…

Now online! STING orchestrates the neuronal inflammatory stress response in multiple sclerosis dlvr.it/T8HhbT

#WeekendRead! #EveryCellIsAnImmuneCell! Marcel Seungsu Woo Christina Mayer Manuel Friese &co show Cell that #InterferonGamma induces STING in #neurons that upon glutamate excitotoxicity detaches from STIM1 to drive ferroptosis aggravating #MultipleSclerosis! cell.com/cell/fulltext/…

Forschende des #UKEHamburg haben in einer Studie einen Mechanismus für das Absterben entzündeter Nervenzellen bei #MS entdeckt und das hierfür entscheidende Schlüsselprotein identifiziert. Damit könnten sich neue Ansatzpunkte für die MS-Therapie ergeben: uke.de/allgemein/pres…

Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by Hong-Gyun Lee doi.org/10.1016/j.molc…

How das chronic hyperexcitability contribute to #neurodegeneration in #MS? Check out our journey published now in Journal of Clinical Investigation with the incredibly talented Lukas Bal 🎓 from the INIMS Manuel Friese 🎉🔥 jci.org/articles/view/…

Out now: How does inflammation impact hyperexcitability and metabolism in neurons during #multiplesclerosis. Again great collaboration Merkler lab Markus Glatzel and others! Spearheaded by the MDs Marcel Seungsu Woo Lukas Bal jci.org/articles/view/…

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

I've recently discovered a really useful R package by Jan Broder Engler called tidyheatmaps. It's designed to make creating heatmaps from tidy data easy, especially for publication-quality visuals. The package uses pheatmap for detailed heatmaps with less coding. If you work

🚀 Thrilled to announce the launch of Phase 2 funding for #SPP2306! After an incredibly productive first phase, we’re ready to push the boundaries of 🔬 science. Huge thanks to everyone for the inspiring discussions and groundbreaking ideas—let’s keep the momentum going! 🔥🔥

Check out our new findings from ⁦INIMS⁩ - Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis | Nature Communications nature.com/articles/s4146…

tidyplots is now on CRAN 🚀 tidyplots.org #tidyverse #rstats #Rpackage #DataAnalytics #DataScience #ggplot2

»Toleranz wird zum Verbrechen, wenn sie dem Bösen gilt.« Am heutigen Tag vor 100 Jahren erschien „Der Zauberberg“ von Thomas Mann.

Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise science.org/doi/10.1126/sc… written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn! Columbia University

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between INIMS UKE Hamburg Fraunhofer-Gesellschaft KU Leuven Evotec cell.com/iscience/fullt…

Manuel Friese Brain great work shedding light on the applications of CAR T cells !

🧠 Once smoldering inflammation begins, neurons may undergo irreversible changes and eventually degenerate, explains Prof. Manuel Friese from UKE Hamburg. Targeting this process is the next big challenge in #MS research. Read more here: bit.ly/3PMkyeQ

We are hiring (2 positions) one Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf uke.jobs/index.php?ac=j… uke.jobs/index.php?ac=j…

Our study on the protective role of CLEC16A in astrocytes in MS is out today in Nature Neuroscience! Congrats to Atsushi and all collaborators! nature.com/articles/s4159…

RVCL is a rare genetic disease that can cause blindness, dementia, and organ failure. McGlasson et al. show that RVCL arises when mutations cause the enzyme TREX1 to mislocalize to the nucleus of endothelial cells, where it causes DNA damage. tinyurl.com/jdh9wpre