
Manuel Friese
@manuelfriese
Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE
ID: 1301749185339953160
http://www.inims.de 04-09-2020 05:09:40
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467 Followers
335 Following

Proud to present our findings in Cell about neuronal STING as integrator of inflammatory and glutamate signals in #multiplesclerosis. Great work by Marcel Seungsu Woo , Christina Mayer , INIMS collaborators Merkler lab The Conrad Lab Markus Glatzel cell.com/cell/fulltext/…


#WeekendRead! #EveryCellIsAnImmuneCell! Marcel Seungsu Woo Christina Mayer Manuel Friese &co show Cell that #InterferonGamma induces STING in #neurons that upon glutamate excitotoxicity detaches from STIM1 to drive ferroptosis aggravating #MultipleSclerosis! cell.com/cell/fulltext/…


Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by Hong-Gyun Lee doi.org/10.1016/j.molc…

How das chronic hyperexcitability contribute to #neurodegeneration in #MS? Check out our journey published now in Journal of Clinical Investigation with the incredibly talented Lukas Bal 🎓 from the INIMS Manuel Friese 🎉🔥 jci.org/articles/view/…

Out now: How does inflammation impact hyperexcitability and metabolism in neurons during #multiplesclerosis. Again great collaboration Merkler lab Markus Glatzel and others! Spearheaded by the MDs Marcel Seungsu Woo Lukas Bal jci.org/articles/view/…







Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise science.org/doi/10.1126/sc… written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn! Columbia University

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between INIMS UKE Hamburg Fraunhofer-Gesellschaft KU Leuven Evotec cell.com/iscience/fullt…


🧠 Once smoldering inflammation begins, neurons may undergo irreversible changes and eventually degenerate, explains Prof. Manuel Friese from UKE Hamburg. Targeting this process is the next big challenge in #MS research. Read more here: bit.ly/3PMkyeQ



Our study on the protective role of CLEC16A in astrocytes in MS is out today in Nature Neuroscience! Congrats to Atsushi and all collaborators! nature.com/articles/s4159…
