Sharing my first paper in Sunney Xie’s lab is now published pnas, in this work, we developed a high-sensitivity single-cell chromatin accessibility profiling method—METATAC, with the help of META chemistry, which is initially explored by Longzhi Tan and DONG XING.

Pleased to see our review out in Nature Rev Immunol! Sergi Cuartero, @G_Stik & myself discuss how 3D genome topology connects to immune cell differentiation and function - including links with immune disease & leukemia. Hope some of you will find it useful! rdcu.be/cVW6O

Interesting work!

Physical folding of the human genome is extraordinarily intricate. Bulk methods such as Micro-C revealed fine DNA structures, but cannot solve single cells. The first new addition to our Dip-C family, scMicro-C, finally brings this power to single cells: biorxiv.org/content/10.110…

I am late. Nice tweetorials by Honggui Wu and Longzhi Tan. Glad to see our work is out in bioRxiv. Check it out!!!

This paper on de novo luciferase design is mind blowing in in 7648 ways, but here's one part I'm watching with special interest: How many designs do you need to test before you hit an ML-generated enzyme that works? nature.com/articles/s4158…

Very exciting!

A new paper presents a statistical framework for power analysis of spatial omics studies, facilitated by an in silico tissue generation method. Ethan Baker Denis s. Broad Institute @HiTSatHarvard OA paper: nature.com/articles/s4159…

Our next Center for Integrated Cellular Analysis virtual seminar will be on 4/4 at 12PM ET Zihan Xu will present 'PerturbSci-Kinetics' a novel combinatorial indexing method to capture single-cell transcriptome, nascent RNA, and sgRNA identity in pooled CRISPR screens. Free registration: nygenome.zoom.us/meeting/regist…

A relay velocity model infers cell-dependent RNA velocity go.nature.com/3GaKgFa

I'm thrilled to introduce our latest technique—LiMCA (Linking mRNA to Chromatin Architecture (LiMCA)), from Sunney's lab SunneyXie, which simultaneously profiles 3D genome and transcriptome with the same cell. Preprint: researchsquare.com/article/rs-321…

Congrats!

A must read on how to use cutting-edge single-cell omics technology to study complex biological problems!

I'm thrilled to share our new #bioRxiv preprint from ⁦Junyue⁩ lab at ⁦Rockefeller University⁩! We present PerturbFate, a high-throughput single-cell CRISPR platform profiling nascent/pre-existing RNA, steady-state RNA & chromatin accessibility. biorxiv.org/content/10.110…

Congrats！unprecedented resolution of 3D genome at single-cell level