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Can Left Ventricular hypertrophy be reversed in kidney transpl recipients with an imtor strategy treatment? 👉🏻Edoardo Melilli adresses with the ENVHIE Study! #ESOTcongress

Congratulations to the top 30 Young Nephrologist Platform (YNP) abstracts in this year’s European Renal Association Congress!! 🤓🇪🇺 ERA - European Renal Association YNP of ERA Francesco Fontana @MariaEl30357435

This review demonstrates that many signaling pathways such as Wnt-Ctnnb1, Hippo, Pi3K-Akt, Rb-E2f or p53-Mdm2 are involved in the regulation of cell cycle re-entry and progression in adult mammalian cardiomyocytes. doi.org/10.1042/CS2021…

What is a crescent? An abnormal response of renal progenitors while trying to replace lost podocytes. Our new study shows reversal of crescents into podocytes is anyway possible and changes disease outcome science.org/doi/10.1126/sc…

The crescent is a clonal lesion generated by expansion of a single progenitor cell reminding stem-cell mediated diseases of the bone marrow. Shown in our new study by lineage tracing of single renal progenitors science.org/doi/10.1126/sc…

Turning crescents into podocytes: the podocyte marker synaptopodin in purple and the renal progenitors in green. Our new study the cover story of Sci Transl Med this week science.org/doi/10.1126/sc…

This week's new issue of Science Translational Medicine has arrived! fcld.ly/v0fdjvb

Thrilled to share our recent work. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice is now available on Science Translational Medicine, and it made the journal cover! Thanks to my mentors Paola Romagnani and Laura Lasagni!

What a journey Maria Elena Melica!!! This project was a life-changing experience. Congrats to you and to our fantastic team, we are all so incredibly proud 💪

Many thanks to my amazing and hard-working colleagues! Giulia Antonelli Roberto Semeraro Maria Lucia Angelotti Gianmarco Lugli Samuela Landini @ RavagliaF Gilda La Regina Carolina Conte LetiziaDeChiara Anna Julie Peired Benedetta Mazzinghi Alice Molli Valentina Raglianti Francesco Guzzi Elena Lazzeri

And also many thanks to our amazing collaborators and mentors from LMU Munich Hans-Joachim Anders and Stefanie Steiger

Proud and humbled to share our recent paper on Nature Communications!It's such a thrill to see the paper finally out! Huge thanks to my PI Paola Romagnani and to Elena Lazzeri How does the kidney adapt to AKI? #polyploidy #AKI #CKD 👇 nature.com/articles/s4146…

Happy to share our newest review paper on #Biomaterials of human source for #3Dprinting strategies 🧪⚡️ Check it out! 👀➡️ doi.org/10.1088/2515-7… via IOPscience Work performed under the scope of a InterLynk-H2020 #H2020 master thesis! 👨🏽‍🎓Well done! COMPASS João Mano

8/ Melica, Paola Romagnani and colleagues found that parietal epithelial cells (PECs) are renal progenitor cells with similarities to the bone marrow stem cell niche. science.org/doi/10.1126/sc…

We just published detailed protocols for preparation of human kidney progenitor cultures and their differentiation into podocytes, a very useful tool for study their biology bio-protocol.org/e4757

Excited to share our new work: Simulated microgravity to investigate glomerular mechanobiology 👇👇 One small step towards #kidney progenitor in #Space🌌🚀 stemcellres.biomedcentral.com/articles/10.11…

Now online in NDT Global epidemiology of kidney cancer Francesca Becherucci Luigi Cirillo academic.oup.com/ndt/advance-ar…

Our new study is out! By STED microscopy on kidney biopsy and ELISA assays we show 1/3 of pediatric and half of adult patients (more in primary FSGS) have autoantibodies against slit antigens different from nephrin. i.e. anti-slit Abs kidney-international.org/action/showPdf…

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!