First time polyamine is visualized in ionotropic glutamate receptor (iGluR) pore. Structures of AMPA receptor complexes with auxiliary subunits y5 and CNIH2. Collaboration with Aryeh Korman and Drew Jones (NYU). Shanti Pal Gangwar Laura Yen Maria Karela nature.com/articles/s4159…

nature.com/articles/s4159…

Pentameric TRPV3: an artifact or a clue to channel function? Many structures of tetrameric TRP channel assemblies have been published. We discuss recent discovery of pentameric assembly of vanilloid TRP channel TRPV3 (doi: 10.1038/s41586-023-06470-1). sciencedirect.com/science/articl…

Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors frontiersin.org/articles/10.33…

Check out our new review: Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. Maria Karela frontiersin.org/articles/10.33…

Special issue call for papers: Developmental Biophysics. ow.ly/cmBz50QrMRb

RIP Jim Howe! Jim was a strong supporter of early career scientists and women in science! He would be sad to see the lack of representation in this otherwise brilliant slate!

Congratulations Art! We are so proud of you and so lucky to have you Biochemistry & Molecular Biophysics

Kainate receptor channel opening and gating mechanism | Nature doi.org/10.1038/s41586…

In today’s issue of Nature! Plant lectin Concanavalin A helped to open the channel of kainate receptor for the first time! The image is a cover candidate that was not selected by the journal. Shanti Pal Gangwar Maria Karela Kirill Nadezhdin Laura Yen Maria Kurnikova disq.us/t/4oqzkgx

Online now! Structure-function analyses of human TRPV6 ancestral and derived haplotypes dlvr.it/TG1DCd

Introducing spIsoNet, a software tool that addresses the challenges of map anisotropy and particle misalignment in cryo-EM caused by the preferred orientation problem. The Zhou Lab Yuntao Liu CryoEM-Fan nature.com/articles/s4159…

Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor #ionchannels | Nature Communications buff.ly/4i8uWdF From @[email protected] #IonChannels

Thrilled to share this contribution to the iGluR field!

Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels | Nat Commun doi.org/10.1038/s41467…

Марсианин youtu.be/Cqy-kMZULS0?si… via YouTube

NEWS🚨: NASA's Peservence rover just sent this image back from Mars

nature.com/articles/s4200…

Happy to share Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes. In collaboration with León D. Islas and Tamara Rosenbaum | PNAS pnas.org/doi/10.1073/pn…

Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes | PNAS pnas.org/doi/10.1073/pn…