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🧵4/5 Grab a coffee and get ready for our final afternoon session, "Longitudinal & Clinical Biomarkers of Aging," moderated by Prof. Michael Snyder (Michael Snyder, PhD). Longitudinal and clinical biomarkers of aging are essential for tracking aging processes over time and across

🧬 Our 2nd preprint today, MethylGPT: A foundation model for the DNA methylome! Our generative pretained transformer-based model: - Trained on 226,555 samples (154,063 after QC & deduplication) - 49,156 curated CpG sites - 7.6B training tokens - Spans 20+ tissue types from

Really excited to be speaking at this meeting in March next year - always one of the best events of the year!

🌟PhD Opportunity🌟 Investigate the links between opioids, other analgesics, and cognitive decline and dementia. Supervised by myself, Simon Cox, MarioniGroup, Sara Hägg, & Barbara Nicholl. Learn more about our PrecisionMed_PhD project and apply below!⬇️ usher.ed.ac.uk/precision-medi…

New publication: DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts Generation Scotland Institute of Genetics and Cancer The Lothian Birth Cohorts Hannah MarioniGroup @RobertHillary Simon Cox Danni Gadd Elena Bernabeu @SarahEHarris99 Read more here: cell.com/ajhg/fulltext/…

Excited to see Elena Bernabeu's DNAm study of alcohol consumption published in Clinical Epigenetics. …lepigeneticsjournal.biomedcentral.com/articles/10.11… Findings include the development of an EpiScore that generalises well across cohorts and assocs with brain health where self-report alcohol doesn't!

#GettingGenomeMe – Genomics Researcher Profile Click below to hear from Institute of Genetics and Cancer and MarioniGroup PhD Student Hannah, who is using statistical techniques to identify blood-based biomarkers for health outcomes. Read more here: onehealthgenomics.ed.ac.uk/hannah-smith

So pleased to see this work published in Nature Communications . Many thanks to the reviewers for their insightful comments and all the co-authors of this study in Edinburgh (Xueyi Shen, Mark James Adams Andrew McIntosh, MarioniGroup) and those who ran analyses in additional cohorts 🧬.

The March edition of The Disconnected Mind Newsletter with news and updates from our team is now available online: edin.ac/41uIdWx School of PPLS CAHSS News | The University of Edinburgh Brain Health Scotland

New publication: An integrative network approach for longitudinal stratification in Parkinson's disease 🧬Ian Simpson🏴󠁧󠁢󠁳󠁣󠁴󠁿 MarioniGroup School of Informatics, The University of Edinburgh Institute of Genetics and Cancer Read more here: doi.org/10.1371/journa…

Nothing seems to have bigger impact on your plasma proteome than the use of hormonal contraceptives. Often misconstrued as age and sex effects, and I'm wondering if we really understand all health implications. nature.com/articles/s4385…

You’ve collected saliva and want to work with epigenetic clocks⏱️ developed in blood DNAm, will you get the same measure? Check out Sepideh Zarandooz's first pub and thread for the answer! doi.org/10.1186/s13148…… #MPRGBiosocial IMPRS on the Life Course (LIFE)

"Epigenetic clocks and DNA methylation biomarkers of brain health and disease" Our review paper is now out in Nat Rev Neurology Eleanor Conole Simon Cox Hannah nature.com/articles/s4158…