Can we use magnetic fields to enhance probiotic colonization of the GI tract without disruptive antibiotics? Yes! Congratulations to Marjorie Buss, Pradeep Ramesh and colleagues on their new paper in Advanced Materials. onlinelibrary.wiley.com/doi/10.1002/ad…

Happy to introduce new Acoustic Reporter Genes with much better expression and imaging performance, identified via a phylogenetic screen and demonstrated in vivo by imaging tumor-homing bacteria. Congrats to Marjorie Buss, Rob Hurt & collaborators! biorxiv.org/content/10.110…

Going from GFP to EnhancedGFP made fluorescent reporters much more useful. Excited to take a similar step with second-generation Acoustic Reporter Genes based on #gasvesicles. Congrats to Mengtong (Tom) Duan, Marjorie Buss, Rob Hurt et al on this updated preprint. biorxiv.org/content/10.110…

Genomically mined acoustic reporter genes for real-time in vivo monitoring of tumors and tumor-homing bacteria go.nature.com/3WM2h3e

New year, new Acoustic Reporter Genes! 🎉 Excited to publish ARG 2.0 – much brighter, easier to express & enabling real-time imaging. ARG2.0 >> ARG1.0 (like mCherry >> original GFP) Congrats Marjorie Buss,Mengtong (Tom) Duan,Rob Hurt et al! go.nature.com/3WM2h3e Caltech HHMI

If light scattering in tissue is causing issues in your research, perhaps it's time to consider acoustic reporter genes (ARGs). Mikhail Shapiro (same on bsky) 🇺🇦's lab shares the newest generation of bacterial and mammalian ARGs in our latest blog post. hubs.la/Q01y-Gr60

Thanks Nature Biotechnology for highlighting our work on this month's cover! Congrats to Rob Hurt, Marjorie Buss, Mengtong (Tom) Duan and colleagues, and the talented Maayan Harel 🟣 Visual storytelling for science who created the artwork. nature.com/articles/s4158…

Congrats to Dr. Marjorie Buss on brilliantly defending her PhD in Chemical Engineering Caltech! 🥂 Marjorie developed 3 breakthrough technologies to image and control probiotics in the GI tract and tumors using ultrasound and #gasvesicles!

Can you use simple diagnostic ultrasound to flip a "diffusion switch" in a hydrogel and deliver drugs? Yes, with Acoustic Percolation Switches! Congrats to Paulene Abundo, Anna Tifrea, Marjorie Buss and colleagues on this advance. biorxiv.org/content/10.110… #gasvesicles

Now we can sense inflammation in the gut using ultrasound. 🔉 Here's how it works: 1. Mice eat probiotic yogurt containing engineered cells. 2. When the cells sense inflammation, they make gas vesicles. 3. These gas vesicles can be "seen" from outside the body using ultrasound.

Can we map gut inflammation with ultrasound? Yes, using probiotic biosensors! 🔊 Imagine drinking a "diagnostic yogurt" and getting an ultrasound instead of endoscopy or colonoscopy 😁. Congrats to Marjorie Buss and collaborators on this advance. doi.org/10.1101/2024.0…