Five years of work, one big question: Which has a greater impact on aging—our environment or our genes? I'm excited to share our paper published today in Nature Medicine, demonstrating the major role of the #exposome in shaping mortality and #aging. nature.com/articles/s4159…

We show that the exposome explains an additional 17% of mortality risk above age/sex, whereas genetics explains only an additional <2%. Cancers like breast and prostate seem more genetic, while heart, lung, and liver diseases seem more environmentally driven.

New in JACC Journals: Harlan Krumholz and I outline how we can apply the lessons from the Celect IVC filter case to enhance transparency and trust in medicine:

Finally set in that I’m moving back home to Boston! Incredibly grateful and excited to have matched in Internal Medicine at MassGeneral Medicine. Thank you to my loved ones, friends, and mentors at NYU Grossman School of Medicine who have supported me throughout this journey! MGH IM Residents #match2025

Get the latest trial highlights from Day 3️⃣ of #ACC25 with #JACC EiC Dr. Harlan M. Krumholz (Harlan Krumholz) & Deputy AE Kushal T. Kadakia (Kushal Kadakia) on #ACCAnywhere TV! 🔹 SUMMIT 🔹 PURSUIT 🔹 ANGPTL-3 🎥 Don’t miss their expert insights! American College of Cardiology youtu.be/A0GCgmsjOD4

Happy to share our new paper in Nature Communications examining the link between strenuous evening exercise and sleep. In ~4 million nights across ~15,000 individuals, we found: 1. Later exercise timing and higher exercise strain are dose-dependently associated with delayed

Dr. Vanka embodies the best of the Harvard Medical School community: a caring and compassionate educator who models empathy and excellence in clinical practice Congratulations to BIDMC Department of Medicine -- there's no brighter⭐️ in medical education!

When I was rotating as a medical student, Dr. Sachit Singal, MD was a star⭐among stars, setting the bar for everything I aspire to be as a doctor I cannot wait for what's to come for you MGH Cardiology Fellows ! I'll do my best to follow in your big shoes to fill Brigham and Women's Medicine Residents

From Kushal Kadakia, MD and co, a needed eval of the 2016 FDA Breakthrough Devices Program ~1 in 10 devices became available sans clinical testing ~1 in 3 used a surrogate primary endpoint ~1 in 7 did not meet their primary endpoint More JAMA Internal Medicine jamanetwork.com/journals/jamai…

MCZ teaching the world about our Z's! Mark É Czeisler, MD, PhD Brigham and Women's Medicine Residents

💤sleep timing/duration→🏃‍♀️next-day physical activity 1️⃣early🐦 exercised more than night🦉 2️⃣ earlier sleep timing w preserved duration was the strongest daily predictor of exercise kudos Josh Leota for the sophisticated analysis & WHOOP AllofUsResearch for real-world data

Paving the way for trials of mesothelin CAR T-cell therapy in patients with refractory meningiomas The one and only Rishab Ramapriyan, MD & co MGB Neurosurgery -- eager to see how you push neuro CAR T-cells forward Penn Neurosurgery !

“Crucially, simply going to bed earlier for a single night - without increasing total sleep - predicted greater physical activity the next day.” Spot on from Will Ahmed WHOOP

🚨1/8 Excited to share the final version of our #meningioma #mesothelin #CART-cell paper, now published SNO with corrected proofs! This preclinical work lays the foundation for applying CAR T-cell therapy to aggressive and treatment-refractory meningiomas. Highlights ⬇️