Check out our preprint on how the pioneer factor GAF localizes to nuclear foci where it represses transcription! This was an amazing collaborative study with Shelby Blythe and Mustafa [email protected] led by grad student Marissa Gaskill. biorxiv.org/content/10.110…

Want to learn more about microscopy?🔬 Apply to #OMIBS, a fabulous 9-day course Marine Biological Laboratory (MBL) in beautiful Woods Hole. Course dates: Aug 14-24, 2023; Applications due May 11, 2023. Co-director Alison North is back! mbl.edu/education/adva…

We’re pleased to share our first publication from the Sozen lab, now out nature! Through our 3D strategy, we capture spontaneous emb. + exembr. lineage bifurcation to study aspects of early human embryo patterning, starting from a single stem cell type. nature.com/articles/s4158…

This week in Science, a study reports “the most precise measurement yet” of the size of the electron’s permanent electric dipole moment. The results have implications for an important unresolved question in physics—the imbalance of matter and antimatter. scim.ag/3fX

🔬🧬 Excited to share our latest study science.org/doi/10.1126/sc… Science Magazine developing ChromExM which uses expansion microscopy to visualize the chromatin, transcription, RNA POL II and pioneer factor Nanog during genome activation.

🔥 new paper led by Mark Pownall from the Giraldez Lab visualising chromatin, transcription, RNA Pol II and PF activity! 👇🏾👇🏼👇🏿👇

A modified protocol for expansion microscopy enables visualization of the spatial organization of chromating. #NBThighlight science.org/doi/10.1126/sc…

Researchers apply #SuperResolution expansion #Microscopy #ExM towards imaging of chromatin in a developing embryo during zygotic genome activation, illuminating how Nanog interacts with nucleosomes and RNA polymerase II. Learn more: bit.ly/3pGNdbG

A new form of expansion microscopy called ChromExM can be used to expand chromatin to visualize transcription at high resolution, according to new research in Science. Learn more ⬇️ 📄: scim.ag/3iy #SciencePerspective: scim.ag/3iz

Technologies to model early mammalian embryo development in vitro have advanced rapidly, providing new insights into self-organization and environmental control. Berna Sozen and I wrote a review as part of a special issue on #earlyembryonicmodels: rb.gy/fkpjk (1/3)

It took Sergey Ulyanov and I a while to shape fountains, a novel type of chromatin architecture. Here is our story of pioneering factors binding (Daria Onichtchouk) and the loop extrusion (Leonid Mirny) working together. (can you tell that I’ve been into fishkeeping since I was six?)

HCR was a great tool to visualize miR-430 transcription with ChromExM in our recent paper!

Very excited to receive an honorable mention among this outstanding group of scientists for my PhD work with Giraldez Lab Yale Department of Genetics Yale University

We have open European Research Council (ERC)-funded post-doc positions to study #3Dgenome organization and #generegulation. We are looking for talented and motivated candidates, but prior experience in the field is not required. Please RT! mpinat.mpg.de/4627722/Aussch…

📣 Congrats to Gal Jaschek, who was recently awarded a highly competitive PhD Fellowship from Boehringer Ingelheim Fonds. Gal is a Yale Department of Genetics graduate student in the Giraldez Lab. 👏 #TraineeTuesday [1/4]

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)