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A big day for DNA gaps! We uncover a role for POLQ, a therapeutic target in BRCA mutant cancers, in single-strand DNA gap filling, led by Anna (Schrempf) Hanzl, Sara Bernardo. Huge thanks to collaborators TFPX NFT || Mint is Live⭕ Marcus Wieder Gerhard Ecker @georg_e_winter cell.com/cell-reports/f…

First #photoswitch paper from the lab!🔥paper in Chemical Communications on one-way #hemithioindigo photoswitches and highly redshifted bipyrrole containing switches! Great work by Mikkel Krell-Jørgensen with help from MSc student Magnus Bonnevie! [1/n] pubs.rsc.org/en/content/art…

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance CeMM @georg_e_winter Alexander Hanzl Fischer Lab #E3Specific #Degrader #Tracing #Receptor #Abundance pubs.acs.org/doi/10.1021/ja…

Thrilled for our Orpinolide story to see the light of day! Huge thanks to the @georg_e_winter lab, Waldmann lab, Luca Laraia and everyone that contributed Hana Imrichova (Novotna), @FabianFrommelt, Laura Depta, Andrea, Chrysanthi Kagiou, Thomas, Cris Mayor-Ruiz, Superti-Furga Lab and Sonja Sievers! 🧵👇

Our paper on 14-3-3 proteins and their role in protein aggregation and phase separation is out! This paper represents the main PhD thesis work by my student Dmitri Segal. 1/ cell.com/molecular-cell…

Very happy to be part of the story from Luca Laraia Congrats to all coauthors, great work! 👇👇👇

I’m really excited to share with you our new paper out in Nature Chemical Biology delving deep into the unexpected diversity of cyclin K molecular glue degraders, with learnings applicable to other #molecularglue systems (1/6) 👉 go.nature.com/44J7zQ6

We've updated our DCAF16-BRD4 preprint with lot new data: structure-design picomolar degraders, glues to a distinct E3 ligase (DCAF11) and revised title: Targeted protein degradation via intramolecular bivalent glues Centre for Targeted Protein Degradation Ollie Hsia @georg_e_winter biorxiv.org/content/10.110…

Happy that this #chembio detective story is out at Angewandte Chemie!💊 🕵️‍♀️ We inform on synthetic lethal interactions to tackle #resistance to #degraders! Special congrats to @BarbMGBarbos Karen Sfyaki Ferran José Duran #Sergi!💜IRB Barcelona ▶️10.1002/ange.202316730 Thread 👇 (1/7)

🔬Inspired by nature: A synthetic nightshade molecule has proven effective against leukemia cells, according to a new study by CeMM PI @georg_e_winter published in Nature Chemical Biology. The new molecule disrupts the cholesterol metabolism of tumor cells ➡️ read more: bit.ly/3VLWHQc

Big day for the lab as our latest paper is out in Nature Chemical Biology Nature Chemical Biology on identifying the oxybipins as new OSBP inhibitors, as well as their mechanism of action and therapeutic applications! nature.com/articles/s4158… 1/n

🔬 Targeted Protein Degradation: A new adapter molecule expands the therapeutic potential around the cell's waste disposal system, CeMM PI @georg_e_winter's team published a new study in Nature Communications : go.nature.com/3zn9Ia2 Read more ➡️ bit.ly/4cmwYn6

We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily (biorxiv.org/content/10.110…)!

Happy that this is finally online! Genetic code expansion approaches to decipher the ubiquitin code Chemical Reviews Many congratulations to Vera, Max and Marco! Vera Wanka Max Fottner Marko Cigler 🥂🎉🥳 pubs.acs.org/doi/10.1021/ac…

Hey Halloween fans, check out our latest paper! We’re diving into the fascinating world of the PIDDosome and how it activates the hitman Caspase-2 to kill cells that fail cytokinesis. Guess what? Caspase-2’s secret weapons are BID and p53! science.org/doi/10.1126/sc…

🏆 Congrats to @georg_e_winter for receiving an European Research Council (ERC) Consolidator Grant for GE|NEomorph, a project reprogramming cancer cells via transcription factors. It opens new avenues for targeted therapies in the fight against #cancer #ERCCoG ➡️ Read more: bit.ly/41h3AMG

A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein degradation nature.com/articles/s4158…