🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

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Today our important study on air pollutants in the promotion of lung cancer has been published in nature led by Will Hill Emilia Lim Clare Weeden Swanton Lab ...Thread below🧵nature.com/articles/s4158…

Biggest thing to ever come out of my little group. Pls help spread this finding! We found clean, CAUSAL evidence that the shingles vaccine prevents a good chunk of dementia cases. So, could a virus cause Alzheimer’s->YES! Hear me out & see preprint: bit.ly/3MVqXU9 🧵1/

So excited to share our work with Tobi Alegbe and @Lelandtlr where we used #singlecell on a large #IBD and healthy cohort to identify gastrointestinal cell types, genes and pathways associated with #Crohns disease ! medrxiv.org/content/10.110…

Very happy to share the latest preprint from my lab, where we benchmarked colocalisation and Mendelian randomisation methods using cis-pQTLs as the ground truth. biorxiv.org/content/10.110…

Fantastic workshop yesterday on using the UKBB to scale up your research by Laura Fachal Aleksejs Sazonovs Jeffrey Barrett Sini Kerminen #ASHG23 #ASHG2023

Absolutely delighted to be at #ASHG2023 on behalf of the IBD Disease Genetics Consortium If you want to hear more about the impact of common variants on IBD susceptibility (ant it’s mayor subtypes) drop me a DM or come to visit poster PB1469 on Friday (3-5pm)

"What sort of idiot makes a poster dependent on internet access in a place notorious for patchy WiFi?" Check out my poster PB125O today at 3 and I can talk you through how we mined the gut for sc-eQTLs #ASHG23 Not at ASHG? Go to the website I made for it tobi1kenobi.github.io/ashg2023poster/

Very pleased to share this exciting project on gene misexpression led by Thomas Vanderstichele. Great collaboration with the INTERVAL study, @minouye271 and Dirk Paul

Study over 1973-2001 not only confirms prior observations of increased cardiac & non-cardiac deaths in the winter, but distinct spikes at Christmas and New Year's Day - particularly pronounced for non-inpatient deaths ahajournals.org/doi/10.1161/01… Circulation editorial

Out now! scSNV-seq is a new method to directly link genotype to whole-transcriptome readout in high-throughput single-cell perturbation screens🧬 Congratulations to Sarah Cooper @mattcoelho3 Magdalena Strauss and the whole team! Wellcome Sanger Institute EMBL-EBI doi.org/10.1186/s13059…

We are hiring a postdoc for our Open Targets project in collaboration with Gosia Trynka lab. A cool collaborative project between academia and industry using CRISPR screens to investigate how genes associated with immune diseases modulate B cell functions. Human Technopole

NEW PREPRINT! We have a new MR method called MR-link-2, which we validated extensively. Interested in Mendelian randomization? A🪡 below medrxiv.org/content/10.110…

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Júlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110…

Fun weekend project idea: apply for a PhD in IBD genomics with us in Copenhagen. Both mathsy and biomedicine types welcome. Great data and, if I can be humble, great people jobs.ac.uk/job/DHC445/phd… #PhDjobs #PhDposition

We’re recruiting for multiple positions in my lab in New York and Stockholm, at MSc and PhD levels. If you’re interested in pursuing creative systems genetics questions with tools/data like Developmental GTEx, CRISPR and single-cell, please read further / share. 1/

Messaging all immunologists who are excited about the potential of large-scale genome editing to understand mechanisms underlying inflammatory bowel disease - this postdoctoral fellowship with @gosiatrynka and I may be right up your street!

Excited to share our latest preprint introducing SAIGE-QTL, a powerful tool for single-cell eQTL analysis! Check it out here: medrxiv.org/content/10.110… #eQTL #scRNAseq #genomics (1/9)

Excited to share this discovery: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life, acquiring toxicity only when quite long (>150 CAGs). biorxiv.org/content/10.110…

Today we report in Nature Genetics the genetic landscape of cancer drug resistance mechanisms from CRISPR base editing screens nature.com/articles/s4158…