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This week's genome editing triumph is a big deal. Here's why erictopol.substack.com/p/the-first-hu…

I’m pro building more housing. Greater density allows for greater specialization. Specialization enables a higher degree of economic complexity and productivity. And higher productivity leads to higher wages. With overall higher wages, private landlords could collect higher rent.

Cable bacteria were discovered more than a decade ago, but I haven't seen a deep article on them yet. Last year, I visited Aarhus University in Denmark (where they were discovered) to learn more about them. So let me break down why I think these microbes are so fascinating...

Trump year-to-date cuts in scientific fields at the NSF Mathematical sciences: -72% Physics: -85% Chemistry: -57% Astronomy: -53% Biotech, energy, and health sciences: -9% Earth sciences: -80% I feel stupid for once talking about DEI threatening science.

Amable recordatorio de que Dinamarca (naranja oscuro) tenía uno de los sistemas públicos de pensiones más sostenible de la Unión Europea. Por cierto, sin cotizaciones a la Seguridad Social. En rojo en la zona superior del gráfico el más insostenible (gracias a las reformas)

✍🏻 «¿Qué proporción del debate público está abordando hoy cuestiones como la mejora del capital humano, el acceso empresarial a los mercados de capitales o las barreras regulatorias al crecimiento del tamaño empresarial?» Martí JM 🌐 sobre #productividad economiadigital.es/ideas/tapa-euf…

Strange to see people holding these 2 contradictory beliefs: a. Firms care about nothing but profit. b. Many jobs are bullshit jobs. "Greedy capitalists employ millions to do nothing" is a bizarre critique.

The pharma miracle machine is almost entirely powered by the US. Instead of appreciating it, left and right are attacking on all fronts--price controls on the market side, cuts to the research funding side. Because no one can see past their immediate political priorities.

Many assume that natural selection will reverse fertility decline as high fertility groups outcompete the rest There are models that support this intuition but if environmental forces or cultural memes are strong enough, the reversal may never come! maximum-progress.com/p/evolutionary…

I am thrilled to share the Alzheimer’s Disease Drug Development Pipeline: 2025 with our fabulous colleague Jeffrey Cummings Very glad to see more diverse targets beyond anti-amyloid drugs. Looking forward pipeline 2026! Thanks The National Institute on Aging (NIA) alz-journals.onlinelibrary.wiley.com/doi/epdf/10.10…

Using data from more than 100 million Americans, we now have an update. Obesity didn't just fall in 2023, it kept falling through 2024. The obesity crisis may really, finally be ending.

📣 Proud to announce the closing of our $135M series B financing co-led by EQT Life Sciences and Sanofi Ventures and with the participation of Roche Venture Fund, as well as all existing investors! With our lead gene therapy SB-007 in the clinic for Stargardt disease and a broad

LAUNCH DAY 🚀 Today I’m launching a new podcast, Hard Drugs, with Jacob Trefethen (Jacob Trefethen) Our first episode is about lenacapavir — a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and which could completely change the fight against HIV worldwide.

The company’s intein-based technology is initially aimed at Stargardt disease, a type of macular degeneration. hubs.li/Q03rG8q20

The National Institute of Statistics of Paraguay estimates the country’s total fertility rate (TFR) at 1.95, already below replacement: ine.gov.py/Publicaciones/… Now, you may be asking: Why should I care about Paraguay (unless, of course, you’re from Paraguay)? Paraguay’s income

Why has fertility suddenly crashed everywhere all at once? There are many factors, which vary across all world regions & over time. But we should also recognise the collapse of coupling. Always open to new data & ideas! 🙂 Graph by John Burn-Murdoch

✍🏻 Primer Premi Ostrom Treball Fi de Grau 2025 🥇 Premiem l'excel•lència en TFGs sobre polítiques públiques, economia i filosofia política 🎓 Els guardonats rebran una beca per cursar els estudis d'un màster 🗓️ Data límit: 30 de setembre 2025 institutostrom.org/premis-ostrom-…

Brad Loncar People age. Inflammation, glucose control, and other atherosclerosis pathways evolve. Even with PCSK9 knocked out with laser precision (long term data) other drivers (e.g., Lp(a), triglyceride-rich lipoproteins) may still accelerate disease. So: cool tool, not a silver bullet.

The growing potential of incorporating genetic information to optimize clinical trial design in cardiometabolic disorders nature.com/articles/s4158…