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Yesterday was already my last day University of Groningen and Membrane Enzymology. What a wonderful year - met a lot of very nice people and fantastic scientists. And also had some time to enjoy the beautiful city of Groningen. Thanks to all who have been part of it!

We have been a bit quiet lately, doubting if Twitter is still a good platform for science, but this one we really wanted to share. Chancie T - chanciet.bsky.social and the rest of the team show how ECF #transporters shed off a subunit by #cryoEM, Cristina Paulino nature.com/articles/s4146…

Excited to share our work on how ECF #transporters use ATP binding to charge a molecular spring and tune the #membrane shape to expel membrane-embedded substrate-binding proteins from the docking site into the membrane. #cryoEM #Biochemistry #MDsimulation rdcu.be/dhJvy

RoseTTAFold updated to be All-Atom... biological assemblies containing proteins, nucleic acids, small molecules, metals, and covalent modifications ... and diffusion🤯biorxiv.org/content/10.110…

My first paper with Cristina Paulino lab just published in nature 🤯: Cryo-EM structures of the sperm-specific SLC9C1, a unique hyperpolarisation-activated transporter! Excellent work by first author Valeria Kalienkova 🇺🇦🌻 - glad to be part of this team! nature.com/articles/s4158… #CryoEM #b3d

I was often asked what I was working on in Cristina Paulino group. Well, here it is! 🥁🥳 What a fascinating combination of ion channel and secondary active transporter domains in one protein! Great teamwork with Martin Peter Jan Rheinberger nature.com/articles/s4158…

Structures of a sperm-specific solute carrier gated by voltage and cAMP | Nature disq.us/t/4jv429o #CryoEM #transporter #MembraneProteins

Membrantransporter sorgen für Mobilität von Spermienzellen: Neu entdeckter Mechanismus trägt zum besseren Verständnis molekularer Grundlagen der Fortpflanzungsfähigkeit bei uni-heidelberg.de/de/newsroom/me…

1/10 With great pride I present our newest #CryoEM work pub. in nature. The 1st reported secondary-active transporter directly activated by membrane voltage. Full credit to the amazing Valeria Kalienkova 🇺🇦🌻, Martin Peter & Jan Rheinberger 🧵👇🏽 for more info nature.com/articles/s4158…

The fun part of having a new protein structure: Making #SciArt a #b3d! Check out our newest nature paper from the Cristina Paulino lab about a sperm-specific, voltage-gated transporter! And thanks to Brady Johnston for #MolecularNodes! nature.com/articles/s4158…

And another blender of SLC9C1!

Interested in stories about structure, mechanism, and ligand modulation of #receptors, #ionchannels and #transporters? Join us at the 2024 #Ligand Recognition and Molecular Gating GRS in Ventura, CA🇺🇸 Apply before Dec 17 for the talk and spread the word! grc.org/ligand-recogni…

🚨 Our next TRAP transporter story from @gha14 lab is published: We used cysteine-cross linking to trap conformational states and analysed domain interactions with sm-TIRF microscopy. Again, very nice collaboration with Kubitscheck Lab and Gavin H Thomas ! nature.com/articles/s4146…

More beautiful data from Martin Peter & @gha14 using Kubitscheck Lab cool sm-TIRF setup to drill down on conformational changes in the TRAP transport cycle. Biology at York York Biomedical Research Institute - inspired by @Chris_mulligan work on VcINDY :-) #sialicacid #TRAPtransporter

The last bit of my work in Cristina Paulino lab finally out in NatureStructMolBiol 🥳 Really cool collaboration with @Lynagh_Lab and then PhD student Mowgli Dandamudi, which worked out a lot better than I could have hoped in the months I had left in the lab! 😊

Check out our newest work on ASCT2. From the long lasting collaboration with my dear colleague Dirk Slotboom Membrane Enzymology with the fantastic Anna Borowska leading the work in collaboration with the Marrink lab Siewert-Jan Marrink 1/2 👇🏼

Could not be more proud to share my first PhD paper with you! Find out what makes an amino acid transporter ASCT2 function as an exchanger: rdcu.be/dPTze