
Takeya Masubuchi
@masubuchitakeya
Assistant Project Scientist @UCSanDiego; #Immunity #Cellbio #Biochemistry #Biophysics #Reconstitution #Microscopy; receptor dynamics and cell communication
ID: 969918415233105926
03-03-2018 12:52:25
9 Tweet
31 Followers
101 Following



Today we report on eLife - the journal mechanisms by which similar immune checkpoint receptors show different preferences on SHP1/2, and that PD1 has an atypical ITIM. Congrats to Xiaozheng Xu Takeya Masubuchi Thanks Review Commons for reviewing & referring our preprint doi.org/10.7554/eLife.…

Thrilled to share our Science Immunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to Takeya Masubuchi for leading
