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Want to extend your spatial transcriptomics measurements to include noncoding and/or non-host RNAs? Check out our method **Spatial Total RNA-Sequencing** (STRS) - out today in Nature Biotechnology! nature.com/articles/s4158… Here's thread with updates since our preprint:

I'm excited to release what I've been cooking up the past few months at Arc Institute BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage

The Influence of Extrachromosomal DNA (ecDNA) in Cancer: Paul S. Mischel will address this topic in the Opening Plenary Session at the AACR Annual Meeting 2025 (Sunday, April 27). Learn more: brnw.ch/21wS4bH #AACR25 Mischel Lab

A lot of fun teaming up with Yung-Hsin Huang, Ph.D. and Howard Chang on this, with key contributions from Ruochi Zhang, zack chiang, and Jason Buenrostro on the tech dev and Matt Jones, Natasha Weiser, and Mischel Lab on the ecDNA analysis. (5/5)

Vevo Therapeutics is now Tahoe Therapeutics (Tahoe Therapeutics (Formerly Vevo)) We loved our old name, Vevo, and chose it for its allusion to vivo, life. But a (much, much, much) bigger company was also using the name for something unrelated and twisted our arm to change it. 🧵

I like the new name! Congratulations Nima Alidoust ! Tahoe-100M is such an important milestone for AI&Biology!

It's not every day that you wake up to a Forbes article covering the great work of your team. We at Tahoe Therapeutics (Formerly Vevo) open sourced Tahoe-100M to start a movement in open data in biology. Thanks Amelia Palermo Briosi, PhD for taking note of that and the thoughtful piece. "By providing

Online now concurrent with the #AACR25 Opening Plenary, by plenary speaker Paul Mischel Mischel Lab: A Guide to Extrachromosomal DNA (#ecDNA): Cancer's Dynamic Circular Genome brnw.ch/21wSfFy

At the #AACR25 Major Symposium on #ecDNA? Read more about ecDNA biogenesis in speaker Howard Chang's recent Cancer Discovery paper: Disparate Pathways for Extrachromosomal DNA Biogenesis and Genomic DNA Repair doi.org/10.1158/2159-8…

Check out our latest preprint, led by Siyu Chen, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…

1/ 🧵 THREAD: Here’s how we solved a 30-year mystery about an HIV drug. 💊 A drug used for over two decades ⚠️ Pulled from the market for cardiac risk 🤯 And no one knew why — until now We found the missing mechanism using our single-cell mosaic dataset, Tahoe-100M. Let’s talk

I’m super honored to be selected, and immensely grateful. Huge thanks, Hypothesis Fund! We are looking forward to doing some fun science! x.com/Hypothesisfund…

First day of #TahoeDeepDive!

Sad to have missed this! It’s a Tahoe weekend! Go Tahoe Therapeutics (Formerly Vevo)

Thank you to Vlaams Instituut voor Biotechnologie (VIB) for inviting me to the conference on Immune Niches in Cancer & Inflammation in beautiful Bruges. Feels like walking into a Disney story. Incredible science!@cell #INCI25

#TahoeDeepDive 💙

On a personal level, it's special to see a dataset go from an idea -> an experiment -> a community like this. What a smart and curious group of people at the leading edge of the Virtual Cell! This will definitely be a moment in time.

Our GPUs are humming, supporting this awesome group ❤️

How can one efficiently simulate phylodynamics for populations with billions of individuals, as is typical in many applications, e.g., viral evolution and cancer genomics? In this work with Michael Celentano, W. DeWitt, & S. Prillo, we provide a solution. doi.org/10.1073/pnas.2… 1/n

🧵1/ We Tahoe Therapeutics (Formerly Vevo) just published a new post on the Tahoe blog—a story of how we used Tahoe-100M, the world’s largest drug-perturbed single-cell dataset, to find compounds that upregulate MHC-I and make tumors more visible to the immune system. Here’s how 🧬🔍👇