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What if we could evaluate disease genetics beyond diagnosed cases? We used AI to represent coronary artery disease (CAD) on a continuous spectrum for rare variant association in >600K individuals. Results are published in Nature Genetics!! link: nature.com/articles/s4158… (🧵)

Low total kidney volume (TKV) is a risk factor for CKD. This study found kidney volume was associated with incident CKD independent of traditional risk factors including baseline eGFR and albuminuria bit.ly/JASN0419

Our newest work using epi and genetics in UK Biobank looking at kidney disease risk factors. A non-linear relationship between TKV and CKD risk! Ahead of print JASN_News with Jianhan Wu Caitlyn Vlasschaert and team!

🎉Congrats 🌟Marco Buttigieg Marco Buttigieg on your successful Master's defence Queens Pathology and Molecular Medicine & acceptance in the Queen's MD/PhD program. Lots more incredible #clonalhematopoiesis #CH research to come from this guy! Thanks also to examiners Andrew Craig @RenwickLab David M. Berman

Terrific CMAJ 5 things to know about resistant hypertension by Swapnil Hiremath @hswapnil.medsky.social et al. cmaj.ca/content/196/26…. My one burning question, how often can this be blamed on excessive licorice?!? 🤓

Promising AI-assisted imaging techniques for improved assessment of PKD. #KidneyWk

Amazing plenary talk from CEO of Verve ⁦American Society of Nephrology #KidneyWk ⁩ - gene 🧬 therapy for cardiovascular 🫀 protection!!

Unedited love song for the kidneys during #nephjc party #kidneywk All the applause go to Timothy Yau

Come hear about new insights in immune cell involvement in AKI, including our work on CHIP, in ballroom 6B this afternoon! 🧬 #KidneyWk

Join us for our 2024 Toronto PKD Scientific Day on Nov 15! Let's learn together about key topics in PKD from experts in the field! You can't come to Toronto? No worries, It's an hybrid event. More info 👇🏾 shorturl.at/6Tdcc

New commentary on UMOD kidney disease in KIReports kireports.org/article/S2468-…

Summary of a new weapon to fight diabetic kidney disease! GLP-1 receptor agonists for the win! Now in CMAJ Irfan Khan, BSc. Kin, MSc. cmaj.ca/content/196/40…

🚨🚨 Our new manuscript is now available online! Co-led with the awesome Mingxiang Teng Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.110…

Study finds that Non-DNMT3A CHIP was associated with CKD progression among individuals with CKD, and Tet2-CHIP mouse models support a causal role in kidney injury. bit.ly/JASN0680 #ASNJASN

In patients with CKD, non-DNMT3A CHIP was associated with cardiovascular disease with an effect size similar to that reported in the general population. bit.ly/JASN0671 #ASNJASN

A thorough discussion on “Autosomal Dominant Polycystic Kidney Disease: 2025 Update” during the activity of Department of Medicine, Nephrology section. Thanks to Dr. Matthew Bruce Lanktree for the presentation 📚