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Characteristics & outcomes of incidentally diagnosed large B cell #lymphoma. Patients have lower stage & IPI scores compared to symptomatic patients. Potential insight into what could be seen with multi-cancer early detection tests doi.org/10.1002/ajh.27… Albert Suheil Atallah-Yunes

Proteomic determinants of renal organ response in light-chain amyloidosis tandfonline.com/doi/full/10.10…. The non-amyloid protein constituents of amyloid plaques identified on mass spectrometry may inform a patients’ likelihood of organ recovery. Taxiarchis Kourelis

In a study of 130 AL #amyloidosis patients with liver involvement, hepatic response rose from 28% at 6 mo to 48% at 24 mo. High baseline ALP (≥4× ULN), deeper hematologic response, kappa type, and frontline ASCT were key predictors of response pubmed.ncbi.nlm.nih.gov/40509545/

Real-world data confirms: adding daratumumab to CyBorD in AL amyloidosis improves outcomes. ✅ Higher VGPR+ (78% vs 60%) ✅ Fewer early deaths (6-mo: 8.8% vs 16.3%) ✅ Better 2-yr OS (82% vs 70%) Best OS boost in stage II. #amyloidosis #mmsm pubmed.ncbi.nlm.nih.gov/40453144/

🫀 In AL #amyloidosis, deeper cardiac responses (CarR) drive survival—but what predicts them? High BM plasma cells ≥20%, kappa isotype, & HR FISH → faster, deeper CarR—independent of hematologic response. Suggests light-chain toxicity matters.pubmed.ncbi.nlm.nih.gov/40400470/