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Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice sciencedirect.com/science/articl…

Congrats to Lorson Lab and colleagues for their new Human Molecular Genetics paper: The NeflE397K mouse model demonstrates muscle pathology and motor function deficits consistent with CMT2E. tinyurl.com/yfwkhve7

New #SkeletalMuscle paper on Ephrin-A5 or EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma in vitro: tinyurl.com/32zb8u4y

Happy to share that our single-cell analysis of muscle stem cells in two DMD models is now published in Cell Death & Disease. We hope this resource benefits researchers in neuromuscular disease and helps to support the development of stem cell targeted therapies for DMD.

New Cell Genomics paper: Extensive differential gene expression and regulation by sex in human skeletal muscle. tinyurl.com/43yrj6kp

New Nature Communications paper: Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle. tinyurl.com/yvr65vm9

New Nature Communications paper: TANGO2 binds crystallin alpha B and its loss causes desminopathy. tinyurl.com/spkj5p85

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy biorxiv.org/content/10.110…

New #SkeletalMuscle paper: Contrasting Becker and Duchenne muscular dystrophy serum biomarker candidates by using data independent acquisition LC-MS/MS. tinyurl.com/3e9xkv43

New #SkeletalMuscle paper: Extensive striated muscle damage in a rat model of Duchenne muscular dystrophy with Dmd exons 10–17 duplication. tinyurl.com/5n87bpc5

New #MolMetabolism paper: microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism. tinyurl.com/2uxm46u5

I am excited to share our latest manuscript, now published in the Journal of Clinical Investigation, which explores the short- and long-term effects of intein-mediated full-length dystrophin expression in a mouse model of Duchenne muscular dystrophy jci.org/articles/view/…

New Cell Stem Cell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. tinyurl.com/yvf4cdch

Thrilled to share that the last paper of my postdoc is now out in nature ! We show how metabolic rewiring through OGDH drives tissue regeneration and stem cell fate. A wild and rewarding ride—huge thanks to Scott Millman, MD PhD and the Lowe Lab ! nature.com/articles/s4158…

Pharmaceutical companies like Eli Lilly and Company (w bimagrumab) explore ActRIIA/B inhibitors to combat muscle loss in cancer, aging, and weight-loss (e.g., Novo Nordisk’s Wegovy). Our new study shows quite complex metabolic effects of these inhibitors 😵‍💫 biorxiv.org/content/10.110…

New PNASNews paper: Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. tinyurl.com/66p47v9p

New PNASNews paper: A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells. tinyurl.com/2tfpb4hu

Congrats to Jeff Widrick, Lou Kunkel, and former members of my postdoc lab for their new #SkeletalMuscle paper: Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy. tinyurl.com/5c6c3xja