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Online now: Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids dlvr.it/TBGwPd

Muscle matters: the effects of medically induced weight loss on skeletal muscle thelancet.com/journals/landi…

Translational and mechanistic evidence implicating mitochondrial oxidants in the development of lipid-induced muscle #insulin resistance in humans Science Advances science.org/doi/10.1126/sc…

Managing #insulin resistance: the forgotten pathophysiological component of type 2 #diabetes thelancet.com/journals/landi… #T2D

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficiency would be predicted to lower energy expenditure and may contribute to propensity for weight regain. biorxiv.org/cgi/content/sh…

New in nature🧬: We discovered why keeping weight off is so challenging - fat cells retain an epigenetic #memory of their previous state, even after weight loss. This helps explain the biology behind weight regain. Excited to share our newest work! nature.com/articles/s4158…

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift sciencedirect.com/science/articl…

Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models Science Advances #weightloss science.org/doi/10.1126/sc…

Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society journals.physiology.org/doi/abs/10.115…