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It is very sad to learn that Martin Karplus passed away on Dec 28 at age 94. He was a scholar and pioneering chemical physicist with great contributions in many areas including molecular dynamics. We interacted many times starting from my graduate time at Harvard. His legacy is

To be or not to be an oxidase? 🧪 Dive into our latest exploration of this classic enzymatic conundrum, now published in @ACScatalysis: 10.1021/acscatal.4c05944. Grateful for the fantastic collaboration with The Colombo Lab, Dirk Tischler, and @fraaije1!

After a remarkable 300 columns, David S. Goodsell 🏳️‍🌈 has retired from the Molecule of the Month. We are so grateful for his service! Janet Iwasa will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details: cdn.rcsb.org/rcsb-pdb/gener…

Hiring! After six months in Miami, I’m excited to officially launch this new journey. Seeking motivated postdocs to join our lab at the UMiami Miller School of Medicine, exploring protein epigenetics and chemical proteomics in cancer and aging. zawanglab.com/publications

Wonderful work and so happy for being part of it.

Writeup of new nature articles from the Brian Liau Lab #chemtwitter news.harvard.edu/gazette/story/…

George M. Sheldrick (1942-2025) ecanews.org/blog/2025/02/2…

Excited to share our latest work with the Fraaije (Groningen U) & Ram (Leiden U) groups on sorbicillinoid natural products in ACS Chem Bio! CRISPR-powered expression in A. niger boosts protein yields, and crystal structures reveal key catalytic mechanisms. pubs.acs.org/doi/10.1021/ac…

📣 There is a new PhD training network that combines computational & experimental enzyme engineering lead by ITQB NOVA to address materials recicability and contribute to a circular economy. Spread the word 🙌

The COMENZE kick-off meeting is happening on March 20-21! 🎉 Partners from 10 host institutions & 3 associates gather online to launch the project, and discuss organization, PhD recruitment & training. Excited to drive enzyme innovation for bio-based polymers! #COMENZE #greendeal

Interested in shutting down two powerful enzymatic sources of ROS? Check out our latest work in J Med Chem on dual NOX2/MAOB covalent inhibitors. In microglia models, it reduces ROS production and proinflammatory cytokines. #ROS #oxidativestress pubs.acs.org/doi/full/10.10…

Happy to share with Brian Liau our work in @naturecomms studying the mechanism of covalent ‘formylators’ that target the histone demethylase LSD1. Our findings offer a glimpse on a new mechanism for drug resistance. rdcu.be/ef9VT

🔬 Introducing COMENZE IRP1: Engineering enzymes to enhance their affinity for solid surfaces. This research aims to improve enzyme immobilization, boosting efficiency in bio-based polymer applications.​ APPLY NOW! #COMENZE #EnzymeEngineering #SustainablePolymers Artur Góra

💥Proud to share our piece on the pioneering women who shaped the field of #biocatalysis and inspired our journeys. Grateful to Ana I. Benítez-Mateos Caroline Emilie Paul and Sandy Schmidt for joining me in dedicating it to the nextgen women in science and to my little doughter Camilla♥️

Andrea Mattevi, Professor at the University of Pavia and ERC Advanced Grant holder, leads COMENZE IRP9. His team designs and characterizes fusion enzymes to support enzymatic polymer degradation and sustainable polymer reuse. 🔗 msca-comenze.eu/application/ #COMENZE #PhDOpportunity

Final Call – Applications close today! Last chance to apply for one of 10 PhD positions in the Horizon Europe-funded COMENZE network. Join top European institutions working on enzyme engineering & sustainable polymers. 🔗 Apply: msca-comenze.eu/application/ #COMENZE #PhDOpportunity

🧵1/ Excited to share our new preprint! “Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesis via Substrate Channeling” A collaboration between Shakhnovich Lab and MatteviLab Read on bioRxiv: biorxiv.org/content/10.110…

📄 Read the full preprint: doi.org/10.1101/2025.0… Big thanks to our teams at Harvard Chemistry, Unipavia , and Faculty of Science, Utrecht University!

🙌 Co-authors: Dianzhuo(John) Wang , Andrea Gottinger , Jio Jeong, Callum R. Nicoll, Junlang Liu , Tereza Kadavá, Domiziana Cecchini, Marco Malatesta, Albert J.R. Heck, MatteviLab , Shakhnovich Lab Questions welcome! DM or reply 👇 #biophysics #metabolism #syntheticbiology

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