
Matthias D. Koch
@matthiasdkoch1
Optically trapped superposition of biophysics and molecular biology, infused with cycling and cooking, to study the mechanical host-microbe interaction (he/him)
ID: 1030503974523359233
https://www.physicsofbacteria.com/ 17-08-2018 17:17:48
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358 Followers
687 Following

Bidirectional pilus processing in the Tad pilus system motor CpaF disq.us/t/4q1rwbt Congrats to Harry Low’s Lab and all the authors!


#Pseudomonas #protein PlzR regulators type IV #pili assembly in a c-di-GMP manner by PilZ/B #interaction. Check our #publication in Nature Communications nature.com/articles/s4146… #microbiology #motility #bacteria #AMR #molecular #biology



Here is our new landmark paper on P. aeruginosa evolution in human lung organoids under antibiotic exposure. Congrats to Lucas A. Meirelles and thanks to Evangelia Vayena and the real LCSB for the beautiful metabolic modeling. nature.com/articles/s4156…

Happy and proud to see this paper online! We resolved the in-situ architecture of the P. aeruginosa Type IV pilus machine and discovered the localisation and role of PilY1. Great collaboration with Jun Liu Lab Lori L. Burrows Brun Lab @PLynneHowell . nature.com/articles/s4146…

Here is a video that summaries the key findings! Once again, special thanks to my wonderful mentor Jun Liu Lab at Yale School of Medicine YaleMicroPath. Lots more discoveries to come at McGill Medicine and Health Sciences Anatomy&CellBiology CRBS McGill !

Our new review on regulation of #T4P type IV pilus assembly #buildingpermits, by PhD candidate Nathan Roberge, is now available for you to enjoy with your morning coffee! 😀 McMaster IIDR McMaster Biochemistry & Biomedical Sciences Global Nexus McMaster Health Sciences journals.asm.org/doi/epub/10.11…

Our work describing the structure and mechanism of the Zorya anti-phage defense system is finally out nature! Led by haidai HU and Philipp Popp in a wonderful collaboration with Nicholas M. I. Taylor Lab, SimonJackson, Alexander Harms et al.! nature.com/articles/s4158…

Please RT📢 3-year postdoc opportunity funded by The Leverhulme Trust ! Join my group Life Sciences to dive into #biophysics of bacterial electrical signalling and #electrophysiology⚡️#bioelectricity 🔋🧫 jobs.ac.uk/job/DLC690/res…

Trick bacteria with light! It took us a very long time to publish this work, but perseverance and teamwork prevailed. @ Ryan McQuillen Xinxing Yang @ Amilcar Perez @Malcolm Winkler @ Erin Goley @ Kumaran Ramamurthi nature.com/articles/s4146…



Poke bacteria with a sharp needle and they poke back in just a few seconds! Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage! Collaboration with Rod Lim's lab Biozentrum, University of Basel + Swiss Nanoscience Institute (SNI)! science.org/doi/10.1126/sc…


Please repost: Postdoc position in antibiotic discovery in a multidisciplinary project w. high-throughput approaches, microscopy, AI, and hit-to-lead optimization Université de Montréal Faculté de médecine Mila - Institut québécois d'IA IRIC. Apply @ [email protected]. See lnkd.in/dVVk4N3s





Major update to BacFighT6: sites.google.com/view/bacfight6/ Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!
