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Next #MedChemCASES webinar: ► 21st, Nov, 5 pm CET. Beth Thomas (STORM Therapeutics Limited): "Discovery of STC15, the First Molecule Specifically Targeting an RNA Methyltransferase Enzyme to Enter Clinical Development" Register for free: us06web.zoom.us/webinar/regist…

Our paper on inhibitors of the Schistosoma mansoni bromodomain SmBRD3(2) is online in J Med Chem (ACS Publications Bio & Med Chem Content). Congrats to Matthias Schiedel, Darius McArdle, Gilda Padalino, Anthony K. N. Chan and the other authors. Great (ongoing) collaboration with karl hoffmann pubs.acs.org/doi/10.1021/ac…

Delighted to share our paper targeting a bromodomain of S. mansoni! Thanks to everyone involved. I look forward to seeing future work from the Conway and Hoffmann group collaboration!

Tomorrow, we start into a new year of exciting #MedCHemCASES with a presentation from Peter Seeberger on "Vaccines, Antibody Therapies and Diagnostics Based on Synthetic Carbohydrates" When: 24th of January, 5-6 pm CET Where: online Register here: us06web.zoom.us/webinar/regist…

Come join us in our next #MedChemCASES seminar given by Dr. Lynette Nejabet (AbbVie) on February 15th at 5 PM (CET). Register for free using this link: us06web.zoom.us/webinar/regist…

I am very happy to share our most recent work on the discovery of a CXCR2-targeted PET tracer, published in the Journal of Medicinal Chemistry. Thanks to Takahiro Higuchi and Michael Decker for being part of this great project! pubs.acs.org/doi/10.1021/ac…

Happy to share our most recent work on fluorescent tracers for the Neurotensin Receptor 1 (NTSR1), which was recently published in ACS Pharmacol. Transl. Sci. Big thanks to all collaborators! pubs.acs.org/doi/10.1021/ac…

Join our next #MedChemCASES webinar with Professor Stuart Conway (UCLA) on Wednesday, April 24th, 5 pm CEST. us06web.zoom.us/webinar/regist… #drugdiscovery #medicinalchemistry #PROTACs #webinar

Interested in glue #degraders? Join us in our next #MedChemCASES webinar on May 16th at 5 pm (CEST) together with Beatrice Ranieri to find out how MRT-2359 was discovered. Register for free using this link: us06web.zoom.us/webinar/regist…

Its is time for our next #MedChemCASES webinar, organized by Gesellschaft Deutscher Chemiker (GDCh) and #NextGenMedChem! Yoshihiro Ishihara from Genesis Therapeutics will give us insights into "Magic chloro" in #DrugDiscovery Register for free: us06web.zoom.us/webinar/regist…

Happy to share our most recent work on fluorescent ligands and small molecule inverse agonists targeting the intracellular allosteric binding site of CCR1, which was recently published in ACS Pharmacol. Transl. Sci. Big thanks to all collaborators! pubs.acs.org/doi/10.1021/ac…

Thanks to Gianluca Sbardella for highlighting our most recent ChemMedChem paper on intracellular CXCR1 and CCR6 fluorescent probes and small molecule antagonists. Also a big thanks to all collaborators! …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

Excited to share our preprint on developing a fluorescent probe that led to the discovery of enhanced antagonists for the IABS of CCR7! A huge thank you to all collaborators for the incredible teamwork! Philipps-Universität Rheinische Friedrich-Wilhelms-Universität Bonn @BaumjohannLab Matthias Schiedel biorxiv.org/content/10.110…

Delighted to share our most recent preprint on fluorogenic triacylglycerols as sensors for a dynamic measurement of lipid oxidation. Many thanks to all collaborators, especially Petra Imhof and Simon Hammann! chemrxiv.org/engage/chemrxi…

Happy to share the news that our recent work on fluorescent ligands for the chemokine receptors CXCR1 and CCR6 was selected for the front cover of ChemMedChem (20/2024). A special thanks to my PhD student Lara Toy for designing this wonderfull artwork.

Delighted to share the news that our work on fluorogenic triacylglycerols as sensors for a dynamic measurement of lipid oxidation has been published in Analytical and Bioanalytical Chemistry. Congrats to Maria Handke for her first first-author paper! link.springer.com/article/10.100…

Don´t miss the last #MedChemCASES of the year with a special event with two great speakers Stefanie Flohr and Christina Lamers followed by a Women in MedChem round table discussion with Anika Tarasewicz and Olivia Boyd. Register for free using this link: us06web.zoom.us/webinar/regist…

Time for the 1st #MedChemCASES of 2025! Join us next week, 4th of February at 5PM CET to learn from Alexandros Vakalopoulos how naphthyridine carboxamides were discovered and their impact for heart failure patients. Free registration: us06web.zoom.us/webinar/regist…

Join our next #MedChemCASES on February 25th, 5pm (CET)! Elena Koltun from Revolution Medicines will present their groundbreaking work on 'Targeting the Oncogenic State of RAS with Tri-Complex Inhibitors.' Registration is free as usual: us06web.zoom.us/webinar/regist…

Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/ac…