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Amazing work from Maximilian Reichert lab and led by Aristeidis Papargyriou. Branching PDAC organoid models to study inter- and intratumoral heterogeneity in 3D and much more. Great summary of the paper by Aristeidis Papargyriou 👇. Congrats!

Congratulations to Maximilian Reichert Aristeidis Papargyriou & team TU München for their Nature Biomedical Engineering article: “Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma” They have created a new pipeline for establishing

Check out this ground breaking work on pancreatic 3D organoid structures by Aristeidis Papargyriou in the Maximilian Reichert lab!

More information: - publication in Nature Biomedical Engineering: nature.com/articles/s4155… - press information of TU München: tum.de/en/news-and-ev… 2/2

Pancreatic #cancer is hard to treat, partly due to the high diversity of pancreatic cancer cells. A team led by Prof. Maximilian Reichert @tu_muenchen has grown tumor #organoids that mimic this diversity, providing a platform to develop & test new treatments. go.tum.de/770892

Want to 👀 real phenotypic differences in #PDAC epithelial and mesenchymal #organoids ? Check these cool videos we made for our recent paper Maximilian Reichert 🤩✌️ 👉 nature.com/articles/s4155… 👉rdcu.be/d3qyD

Branched organoids that represent the diversity of cell types, their shapes and phenotypic plasticity found in #pancreaticcancer (PDAC) 📷: Aristeidis Papargyriou et al Maximilian Reichert lab TU München in Nature Biomedical Engineering ➡️: bpod.org.uk/archive/2024/1…

Join the International Heidelberg Organoid Meeting 2025 🧠🫀🫁🔬March 20-21 @ Marsilius-Kolleg Heidelberg! With exciting keynotes and abstract-selected posters & talks, iHOME will cover organoid research from basic to clinical. Limited spots; register now: indico.dkfz.de/event/1249/

Thrilled to announce another #iHOME2025 keynote: Maximilian Reichert at TU München “Mapping Tumor Cell States in Pancreatic Cancer with Advanced Organoid Technology.” Hear how organoid approaches reveal key cancer plasticity mechanisms! Register here: indico.dkfz.de/event/1249/

We found that activating programmed necrosis through genetic or pharmacological interventions might be an effective anti-cancer-strategy in pancreatic cancer. Thanks to all collaborators and funders! Mathias Heikenwälder Heinrich-Heine-Universität Düsseldorf Maximilian Reichert nature.com/articles/s4146…

Another great success and very promising collaboration to understand how metabolic mechanism induce vulnerability of particularly #COPD and #Cancer development, with Maria Rohm StefanHerzig, Pullamsetti Lab Alexander Bartelt KarstenHiller Maximilian Reichert Helmholtz Munich | @HelmholtzMunich #HelmholtzLung

💫 Exciting news! Our collaborative Deutsche Zentren der Gesundheitsforschung (DZG) project on inter-organ metabolomics in #cachexia and #COPD received funding. 🏆 Looking forward to working with this amazing team: Önder Yildirim Helmholtz Diabetes Center (HDC) Alexander Bartelt Pullamsetti Lab Maximilian Reichert Deutsches Zentrum für Diabetesforschung (DZD) DZHK Germany

Happy to share our new publication in Nature Communications: "A decision point between transdifferentiation and programmed #cell death priming controls #KRAS-dependent #pancreaticcancer development" nature.com/articles/s4146… TU München Aristeidis Papargyriou Katja Steiger Hana Algül Maximilian Reichert

Hey there! Our paper on ecDNA in pancreatic cancer is online nature.com/articles/s4158…. Thankful to our amazing friends and collaborators Peter Bailey, Andrea Sottoriva, and everyone supporting us through this journey Fondazione AIRC per la ricerca sul cancro, PRECODE Project, Fondazione Nadia Valsecchi ETS, Italian Pancreatic Cancer Community I-PCC,

The #iHOME2025 conference is off to a great start DKFZ! We're excited for 2 days filled with cutting edge organoid science from our speakers, including Treutlein lab, Maximilian Reichert, Joep Beumer and Kim Jensen.

Read the In the Spotlight commentary "The Biology in the Pattern" by Maximilian Reichert and Aristeidis Papargyriou discussing a recent Nature Cancer paper by Jason Link, Rosalie Sears et al. brnw.ch/21wRsVj

HUGE congratulations to Linghua Wang, MD, PhD & team for her latest Cancer Cell study Integrative analyses of over 14 million cells from 10 cancer types across 7 spatial transcriptomics and proteomics platforms identifies four distinct spatial CAF subtypes conserved across cancer types

Early bird registrations are open for Organoids Are Us 2025! Join for the latest research and discussion on organoids, stem cells, cancer, inflammatory disorders and infectious disease. 🗓️ 23 - 26 SEP 📍 Hosted by CRUK Scotland Inst Learn more and register 👉crukscotlandinstitute.ac.uk/events/organoi…

🤩Super excited our branched #PancreaticCancer #Organoids to capture tumour heterogeneity made it on the cover of Nature Biomedical Engineering 🙏🏼nature.com/natbiomedeng/v… TU München VomLaborInDiePraxis @TUMKlinikum Aristeidis Papargyriou Reichert Lab

What a great day! 😁 Very happy to see the latest cover of Nature Biomedical Engineering featuring our paper from my PhD work with Maximilian Reichert TU München on #Organoids capturing tumour heterogeneity!! Thanks to an amazing team! 🤩 Thanks to Ella Marushchenko for the cover ☺️! nature.com/articles/s4155…