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For the clinical application of AI, accurate point predictions are not sufficient. A correct estimate of the uncertainty for each prediction is necessary to highlight cases, that require human inspection. AMD study based on the NGBoost library from the Andrew Ng group

Study supports the validity of reading performance as endpoint in clinical trials and suggests that measures in clinical and low vision care of patients with geographic atrophy secondary to AMD should focus primarily on the better-seeing eye ja.ma/3ASlBAG

Reading Performance in Geographic Atrophy Secondary: The topography of #GeographicAtrophy and central acuity explain ~70% of the variability in reading acuity and speed. Uniklinik Bonn Moran Eye Center Moritz Lindner DOG-Augenheilkunde NEI

Very excited to move my research forward with VERI. If you are interested in any of the work I do please get in touch to discuss opportunities to work together or work on a PhD project. I work hard on inclusivity so welcome queries from all backgrounds.

Inner Retinal Degeneration in Pseudoxanthoma Elasticum Summary: Given the severity of inner retinal degeneration in a subset of PXE patients, a clinical trial investigating neuroprotective therapy warrants consideration. dx.doi.org/10.1136/bjopht… KHess PXE International Uniklinik Bonn

Our latest research on the genotype-phenotype relationship in Stargardt disease. NEI JCI insight insight.jci.org/articles/view/…

#NEIfunded research classifies vision loss and retinal changes in Stargardt disease . Learn how: nei.nih.gov/about/news-and…

Schmitz-Valckenberg et al. Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both doi.org/10.1001/jamaop… NEI Moran Eye Center JAMA Ophthalmology

New Manuscript: Choriocapillaris Flow Signal Impairment in Sorsby Fundus Dystrophy doi.org/10.1159/000520… KHess Young Retina Specialists ProRetinaDE NEI

Just out in Neuron! Across cortical layers, only layer 5 pyramidal neurons synchronize their activity during anesthesia-induced loss of consciousness. #neuroscience #anesthesiology #research Botond Roska Neuron

Association of Complement C3 Inhibitor Pegcetacoplan with Photoreceptor Degeneration Beyond Areas of Geographic Atrophy medrxiv.org/cgi/content/sh… #medRxiv

Combining traditional eye imaging + adaptive optics… Johnny Tam & colleagues (NEI intramural) show for the 1st time how RPE cells are affected in people with choroideremia. Rongwen Lu Maximilian Pfau Medical Genetics & Ophthalmic Genomics Laryssa Huryn, MD Communications Biology: go.nature.com/3L8FUzP

La clinique ophtalmologique de l’Hôpital universitaire de Bâle recherche actuellement des participants pour l'étude ‘First Orbit’. Un traitement pour la maladie de Stargardt associée à le G1961E variant est actuellement en cours de développement. retina.ch/fr/actualites/…

La clinique ophtalmologique de l’Hôpital universitaire de Bâle recherche aussi actuellement des participants pour l’étude d’évolution naturelle Pro-PXE (Progression Rate of Pseudoxanthoma Elasticum-related Choroidal and Retinal Degeneration). retina.ch/fr/actualites/…

Aufgepasst! Am IOB.ch läuft gerade die Bewerbungsphase für das neue MD/PhD-Programm "Translational Visual #Neurosciences". Wer zum #Auge, zur Verarbeitung visueller Eindrücke und zu neuen Therapien forschen will, kann sich bis zum 18. November bewerben! x.com/IOB_ch/status/…

Kristina Pfau KHess et al. Uniklinik Bonn quantify choriocapillaris flow alterations in patients with pseudoxanthoma elasticum (PXE) in pre-atrophic stages and its association with structural changes of the choroid and outer retina. doi.org/10.1167/iovs.6…

Read more about the exciting new results of a collaboration between IOB and Beam Therapeutics on developing a precision gene editing therapy for blindness here biorxiv.org/content/10.110…

Our latest work: Natural-History of Visual Dysfunction in ABCA4-retinopathy and its Genetic Correlates doi.org/10.1016/j.ajo.… NEI IOB.ch

Establishing Fully-Automated Fundus-Controlled Dark Adaptometry: A Validation and Retest-Reliability Study medrxiv.org/content/10.110…

What a brilliant keynote by Maximilian Pfau 👏👏 Congratulations! So we'll deserved