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The PRIMED consortium represents an effort to share genetic data and develop polygenic risk scores that work equally well across ancestries. Important step towards addressing the historical oversampling of Europeans in GWAS studies. 🔗cell.com/ajhg/fulltext/…

📢Online now! 📰The PRIMED Consortium: Reducing disparities in polygenic risk assessment 🧑‍🤝‍🧑Iftikhar J. Kullo Pradeep Natarajan @johnwitte & PRIMED Consortium colleagues cell.com/ajhg/fulltext/…

1/2 Associations of Race, SDOH & PRS with CHD risk in the All of Us dataset by Kristjan Norland tinyurl.com/mt2j6f5m ⬆️ odds of CHD in people who self-report as Black are due to a higher SDOH burden Emphasizing Race as a social not biological construct

SDOH and PRS were independently associated with CHD Including both PRS and SDOH in CHD risk models could improve their accuracy Accompanying editorial by Dr. Nilay Shah here tinyurl.com/2rvmrnxe

A new Perspective from @PRSDiversity is out in AJHG! PRIMED is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations and genetic ancestries🧵 1/ cell.com/ajhg/fulltext/…

See also this report by Satterfield et al. describing MR phenome wide analyses of genetically predicted Lp(a) levels It is unclear, however, whether Lp(a) is equally atherogenic in individuals of African genetic ancestry. pubmed.ncbi.nlm.nih.gov/34282949/ #LPA

With more layers of data, our ability to predict a person's risk of heart disease is getting better and better acpjournals.org/doi/10.7326/AN… Annals of Int Med adding in social determinants of health, lifestyle, and other data Iftikhar J. Kullo UK Biobank

Model shows how data on genetic, social, and lifestyle-psychological factors help better predict individual heart disease risk. bit.ly/3VvrIaq Mohammadreza Naderian Mayo Clinic CV Iftikhar J. Kullo Mayo Clinic

1/2 A UK Biobank analysis by Mohammadreza Naderian highlights the value of incorporating social & environmental factors as well as #PRS to improve CHD risk prediction Main findings: 1 SD increase in a polysocial score led to a HR of 1.43 & a 1 SD increase in PRS led to a HR of 1.59

Polysocial score (PSS) was higher in non-whites The greater CHD risk in non-whites may be partly due to higher PSS The effect of PSS and PRS on CHD risk was independent and additive At a 7.5% 10-y risk threshold, adding both PSS and PRS led to a 12% reclassification rate

Looking forward to a great meeting in a great location! This is our 8th CME course on CV genomics covering general principles, monogenic & polygenic conditions, as well as exciting advances in therapy Privileged to co-direct with the Michael J. Ackerman MD,PhD and Naveen Pereira

Iftikhar J. Kullo is now sharing insights on the interpretation and utilization of polygenic risk scores in clinical practice, helping attendees learn how these scores are transforming personalized medicine. Mayo Clinic Mayo Clinic CV #CardioGenetics #HeartHealth #GHRC #genetics

We are joined by the team of Michael J. Ackerman MD,PhD Iftikhar J. Kullo Teresa Kruisselbrink and Naveen Pereira for the final panel of the day. These experts and attendees are diving into the latest advancements, challenges revolving around genetic cardiology! Mayo Clinic CV Mayo Clinic #genetics

1/3 📊 Excited to share our latest publication in Annals of Int Med from Mayo Clinic Kullo Laboratory, Iftikhar J. Kullo, as a step toward a more personalized risk prediction for CHD 🫀 acpjournals.org/doi/10.7326/AN…

About to wrap up Session III w/ my friend & co-director ⁦Iftikhar J. Kullo⁩ sharing exciting advances in the familial hyperlipidemias. Love seeing the desire in our 100+ attendees to become more fluent in the language of #Genetic #Cardiology.

⁦Roxanne Coderre⁩ at our 8th CV genomics course presenting a Case of very severe hypercholesterolemia due to compound heterozygosity in LDLR

Read about how including genetic, social, lifestyle, and psychological factors in clinical risk calculators for #heartdisease could improve their ability to predict coronary heart disease: bit.ly/4geejMh

🗓️TOMORROW! Learn how the NIH's PRIMED Consortium is advancing equitable polygenic risk predictions via its methods and tools w/ speakers Iftikhar J. Kullo, MD, & Sarah C. Nelson, MPH, PhD. It's not too late to register 👉 learning.ashg.org/products/overv… #ASHG

Trending now at Annals.org: Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank: bit.ly/40uUwBG Mayo Clinic

Disclosure of high genetic risk is often associated with no significant measures to mitigate risk Mohammadreza Naderian & I comment on a syst review on behavior outcomes after disclosing CV genetic risk Genetic risk disclosure and behavioural change: not so fast tinyurl.com/mr2zv7yb