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First paper out from Cene Jerele's doctoral project. We looked into a radiological scale for cholinergic system in patients with Lewy bodies. Data from the Sant Pau Memory Clinic in Barcelona Spain. LBDA Lewy Body Dementias PIA Lewy Body Society Karolinska Institutet Sant Pau Memory Unit

Wouldn't it be great if we could not only image large connectomic volumes, but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (biorxiv.org/content/10.110…), we preview a future where it doesn't have to.

🚨 New preprint 🚨 We introduce Generative Distribution Embeddings (GDEs) — a framework for learning representations of distributions, not just datapoints. GDEs enable multiscale modeling and come with elegant statistical theory and some miraculous geometric results! 🧵

Using longitudinal modeling + neuroimaging, we show that 2nd-generation epigenetic clocks (DNAmPhenoAge + DNAmGrimAge) predict Alzheimer’s progression and are associated with cortical thinning and WMH. nature.com/articles/s4440… Congrats L. Bonham & Michael Corley! Hernando Santamaría-García

Cell-type deconvolution methods for spatial transcriptomics | Nature Reviews Genetics nature.com/articles/s4157…

A really nice paper out today from the Wang lab describing OmiCLIP, a visual–omics foundation model linking H&E images and transcriptomics, and the associated Loki analysis toolkit. nature.com/articles/s4159…

A university-scoring method that highlights research-integrity ‘red flags’ could make it easier to spot institutions that are chasing conventional publishing metrics at the expense of rigorous science go.nature.com/4dSwGGp

Interesting - researchers present integrative multi-omics analyses & preclinical model data supporting the repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for #Parkinsons nature.com/articles/s4153…

Final version of this paper with Alexis Pietak is now out: sciencedirect.com/science/articl… "Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine" Abstract: gene regulatory networks (GRNs) are critically important for efforts in biomedicine and

Epigenetic reprogramming as a strategy for treating neurodegeneration 🧠 tinyurl.com/ys4eh9yw

Dr. Lei Yu and colleagues identified 3 distinct biomarker profiles, among which one profile exemplifies older adults with high burden of AD pathology, and another exemplifies those with more severe vascular conditions. doi.org/10.1093/brain/…

Excited to share our new work on knowledge tracing approach to personalized education, with a real-world, prospective evaluation in Harvard Medical School AI in Medicine 2 course zitniklab.hms.harvard.edu/AIM2, led by Grey Kuling 🧠📚 arxiv.org/abs/2507.00032 What's new? Knowledge tracing blends

The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics Nature Medicine Tony Wyss-Coray nature.com/articles/s4159…

1/6 Excited to share our latest preprint: "MORPH Predicts the Single-Cell Outcome of Genetic Perturbations Across Conditions and Data Modalities". 🔗 biorxiv.org/content/10.110… 🧵 👇 Here is what MORPH is in a nutshell!

🚨 Postdoc Positions at Montreal Neurological Institute's Personalized Medicine lab for multi-omics, neuroimaging and computational modeling of neurodegeneration (AD,PD,ALS). See neuropm-lab.com/open-positions…. Example work👉 science.org/doi/10.1126/sc…

From political unrest to toxic air and social stress, the world around us can accelerate the aging process. Out today in Nature Medicine: our work on how the environment seeps into health and makes us older 1/6🧵 doi.org/10.1038/s41591… Eric Topol Jay Van Bavel, PhD Global Brain Health Institute

Deliriously excited to share our new Neuron Perspective on transformative neuropathology—a roadmap to accelerate brain health discoveries through broader support of brain banks with tech-enabled, team-science approaches to tissue. 🧠 Perspective article: cell.com/neuron/fulltex…

What are "omics"? A good schematic cell.com/neuron/fulltex… could add epigenomics, immunomics, microbiomics, glycomics, exposomics, etc

🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form 🔗 Paper: nature.com/articles/s4225… 📖 News & Views: nature.com/articles/s4225… 💻 Code: corneto.org 🧵 Thread 👇

The #FiberDataHub is approaching 50,000 ready-to-use datasets and now has a citable reference: nature.com/articles/s4159… Though often used with #DSIStudio, the hub is an independent resource that can be accessed using Python and used by DIPY, MRtrix and other tools!