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1. BANKSY is out! go.nature.com/4bUR200 Our spatial clustering algo applies to any spatial RNA/protein/... assay, scales to 2M cells, detects both cell typing and spatial domains and facilitates spatial batch correction. 🧵 👇

So much good science and fun with old and new friends at #KSCardioEpi24 Hannover Harrenhausen palace. Till we meet again ! #Cardiovascular #Epigenetics #GeneRegulation

This Python library works like magic! ✨ With a single line of code & the two matrices you see in the image below, I can find: - a consensus label - quality score for individual & consensus labels - overall quality score for each annotator Introducing CrowdLab! 🚀 A weighted

We've found that the cell adherens junction is crucial for cardiomyocyte development through the NF2-YAP-AMOT protein complex Yong Loo Lin School of Medicine NUS Research NUS CVD Programme Foo Lab Mick Lee

#OriginalResearch: NF2, an upstream regulator of Hippo-YAP pathway, regulates epithelial mesenchymal transition in early cardiovascular lineage commitment. @meekelee Roger Foo ahajournals.org/doi/10.1161/CI…

#ICYMI: Asns marks cardiomyocyte dedifferentiation @yike_zhu Foo Lab NUS Yong Loo Lin School of Medicine @chesterleedrum @zentiang @meekelee @Circulation Roger Foo #AHAJournals

Farid Kadyrov in ⁦Lavine Lab⁩ show that Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury ⁦Nature Cardiovascular Research⁩ nature.com/articles/s4416…

YAP activation induces adult cardiomyocyte division by promoting cytoskeleton disassembly and mitotic rounding jkim Rich Gang Li Shijie Liu Jim Martin ahajournals.org/doi/abs/10.116…

🎉Excited to finally share that our new work (previously bioRxiv) is now online at nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s4158…

Check out the work on targeting IL-1 in heart failure from the legend Junedh M. Amrute as well as a sister paper by Michael Alexanian from previous post!

We use Multiome and HiC to build a comprehensive single cell variant to enhancer to gene map for coronary artery disease. Join effort with Paul Chungroh Lee and IttaiEres in Nate Stitziel Lab and in collaboration with Amgen 🧪🔬🧬 Test Account medrxiv.org/content/10.110…

Introducing scE2G: a new model to link enhancers to target genes using single-cell data. Excited that scE2G will enable building enhancer maps in hundreds of cell types in the human body! Wonderful collaboration with Robin Andersson Wei-Lin Qiu maya sheth and others 👇

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

Thank you AJP-Heart and Circ for publishing our recent work on BRD4 in cardiac macrophages. Huge effect on MHC-II levels. doi.org/10.1152/ajphea…. Great team effort and collaboration with many, including Ron Vagnozzi and Michael Alexanian.

Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues Joseph C Wu, MD, PhD, Sakthivel Sadayappan, PhD, MBA and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug

We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in human coronary artery disease and show that treatment with an anti FAP bi-specific T cell engager reduces plaque burden in vivo biorxiv.org/content/10.110…

Our first foray into using AI to tackle human cardiac fibrosis. ahajournals.org/doi/full/10.11…. Amazing collaboration with Gregory Way and waysciencelab.com. Spearheaded by Josh Travers and Jenna Tomkinson. Tip of the iceberg. Stay tuned!

A lab becomes super exciting when it gets made up of super bright young people (not referring to me), so somewhat shamelessly doing a shout out here for their incredible effort. Started by crowdsourcing, an iPS cell bank here now in Asia. "We are open for business" Yong Loo Lin School of Medicine

Special thanks to Issei Komuro and the amazing organizing committee for a fantastic meeting #ISHR2025 Nara. The bar has been set very high for future ISHR meetings. Congratulations to postdoctoral fellow Marion Delaunay for giving an invited lecture and winning a poster award!

Circulation Research Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos ahajrnls.org/3ZtHfJQ by Roger Foo Joseph hill Faiez ZANNAD Shahzeb Khan Jennifer Ho Leah Kosyakovsky et al