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Our new work lead by the amazing Justine Hill provides insight into the brain’s dynamic functioning at rest. We show a pharmacological impact on brain dynamics and a link with cortical-striatal functional connectivity. Cole Korponay

🚨 A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder insight.jci.org/articles/view/… NIH Intramural NIDAnews NIAAA News JCI insight MONICA FAULKNER Brittney Browning Allison Daurio, PhD Vikas Munjal @IAmSusanPersky Lorenzo Leggio

🚨 Bariatric surgery and alcohol and substance use: A case-control survey study sciencedirect.com/science/articl… NIH Intramural NIDAnews NIAAA News Lorenzo Leggio Claire Pince @sal_giorgi @B_Curtis03 @DrugAlcoholDep

#NIH #NIHproud #SupportNIH

The world is falling apart, but big paper accepted, so:

🚨 Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake. Super proud of this work supported by and done at NIH. NIH Intramural NIDAnews NIAAA News Christopher T. Rentsch Lorenzo Leggio Journal of Clinical Investigation jci.org/articles/view/…

Findings by #NIH/#NIAAA researchers led by Dr. Lorenzo Leggio suggest GLP-1R agonists can be effective to reduce AUDIT-C scores, and that reductions in drinking are more pronounced among individuals with alcohol use disorder. Read the article: jci.org/articles/view/…

We do!

Convergent findings across humans, including real world data, as well as studies in mice, and rats indicate that GLP-1RAs but not DPP-4Is reduce alcohol consumption and may be efficacious in treating alcohol use disorder Journal of Clinical Investigation jci.org/articles/view/…

🚨 Utilizing Blood Inflammatory Markers in Alcohol Studies: Considerations and Recommendations for Study Design, Sample Collection, and Data Analysis sciencedirect.com/science/articl… Dr. Erica Grodin Hollis Karoly, PhD Brittney Browning Leon G Coleman Jr NIDAnews NIAAA News NIH Intramural

💉 What if a weight loss drug could help fight addiction? IHV researcher Dr. Sarah Kattakuzhy is exploring how GLP-1 agonists might treat cocaine use disorder — a potential breakthrough backed by NIH. 🎥 Watch the clip: #BreakthroughsCantWaitUMB

Endorse 👇

Anecdotal reports and animal studies suggest drugs like Ozempic reduce alcohol consumption. @mehdifarokhnia Lorenzo Leggio & team NIH now present a pharmacoepidemiologic study examining showing GLP-1RAs but not DPP-4 inhibitors reduce alcohol intake: jci.org/articles/view/…

It's #InternationalClinicalTrialsDay! 🥼 Are you interested in learning more about research at NIDA in Baltimore, MD? NIDA welcomes participants to join our ongoing research studies. Go to our Research Studies page & click “Find a study” to learn more! go.nih.gov/Rm1CAfB

#RSA2025 #RSA_ISBRA2025

NIDA IRP Featured Paper of the Month – July 2025 irp.nida.nih.gov/featured-paper…

Excited to talk GLP-1 and addiction this weekend! Thanks Endocrine Society for the invite ✨