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Extremely excited to open the registration for the 2nd Annual Variant to Function Symposium hosted by the Novo Nordisk Foundation Center Broad Institute co-Chaired by Melina Claussnitzer, Ph.D.. A stellar (!!) lineup of speakers & virtual+physical attendance. Please share! broadinstitute.swoogo.com/V2F

Our watching party getting ready to dive into what will sure be an excellent talk by Melina Claussnitzer, Ph.D. 🤯 at the V2F symposium hosted by Novo Nordisk Foundation Center Broad Institute

Ever considered measuring genetic variant effects with prime editing but hesitated due to low and variable editing? Last month, 3 papers showed that large-scale screens can work 💪. A 🧵 comparing the papers of the Francisco J. Sánchez-Rivera lab, the Britt Adamson lab, and Greg Findlay

Among patients with obesity-related heart failure with preserved ejection fraction & type 2 diabetes, semaglutide produced greater reductions in symptoms, physical limitations & body weight than placebo at 1 year. Full STEP-HFpEF DM trial results: nej.md/3TPKpUC #ACC24

Analysis of continuous #GlucoseMonitoring measurements from nondiabetic individuals uncovered inter- & intraindividual variabilities, w/ implications for diagnostic cutoffs for #Diabetes diagnosis & several cardiometabolic clinical measures. Eran Segal nature.com/articles/s4159…

Inspired by Lior Pachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics #Bioinformatics

Check out our paper: Minimum information and guidelines for reporting a multiplexed assay of variant effect. Great team effort through the AVE alliance Atlas of Variant Effects Alliance Melina Claussnitzer, Ph.D. Victoria Parikh, MD Alex Wagner Benedetta Bolognesi Alan Rubin genomebiology.biomedcentral.com/articles/10.11…

Messaging all immunologists who are excited about the potential of large-scale genome editing to understand mechanisms underlying inflammatory bowel disease - this postdoctoral fellowship with @gosiatrynka and I may be right up your street!

Heading home from #bog24 on the overday flight (sorry to miss the last session) and here are some thoughts from this Biology of Genomes

In private conversations, people express widespread and extreme concern for the climate, the planet and our future. Many people are terrified. This is in stark contrast with the mainstream society & politics pretending we can continue business as usual. We need to talk. 🌍🧵

BREAKING: The European Union just issued a letter to Elon Musk demanding that he censor Donald Trump in their upcoming interview. Threatening him with "legal obligations" if he fails to stop the "disinformation" Europeans are interfering in American elections "This notably

MSc Anniina Tervi from Hanna M Ollila's group will defend her doctoral dissertation "Environmental Modulation of Genetic Risk for Complex Diseases" on 8 January 2025 at 14:00. Melina Claussnitzer, Ph.D., Harvard University, will serve as the opponent. Welcome! 🔗helsinginyliopisto.etapahtuma.fi/flamma-2019/en…

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We are excited to bring together leaders in human genetics with PhD students in this summer school! 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at lpshg.com

One month until the CSHL Biology of Genomes abstract deadline! My all-time fav meeting, and one of the few covering genomics broadly. We have a ✨🤩 lineup of speakers, but it's the abstract talks & posters that make the meeting - send us your best work! meetings.cshl.edu/meetings.aspx?…

📣Excited to share our paper in Nature Genetics! rdcu.be/d7mo0 Do plasma proteins mediate obesity’s effect on CAD risk? →Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin as a mediator & potential therapeutic target A

🚨Job alert! 🚨 We are hiring a computational postdoc or PhD student focusing on - modeling gene regulation using single cell data - investigating the mechanisms of regulatory genetic variants PhD student: employment.ku.dk/all-vacancies/… Postdoc: employment.ku.dk/faculty/?show=…

I wrote up an FAQ about the recent federal grant cuts. A few key points 🧵:

Brilliant speech by a French senator on the Trump situation.

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Nice new preprint led by Christoffer Nellaker and Melina Claussnitzer, Ph.D. that builds on our early work of studying the genetics of adipocyte size and shape using large-scale multi-cohort digital pathology and human genetics to identify 2 loci controlling adipocyte size: medrxiv.org/content/10.110…