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How much do you know about food and drug safety? Where did our current regulations come from? And what were some of the greatest scandals that forced change? We covered everything from swill milk, patent medicines, and thalidomide in our class today. Here's what we covered 🧵

I can't figure out if vaccines work or not. Tough one. I can see why RFK Jr is so concerned. Need Sherlock Holmes on this one.

Hanging on to every brilliant word by Renée Shellhaas, MD, MS at #CNSAM but particularly love this slide:

Where do I file my refund request for the thousands of dollars in NJ Turnpike tolls I’ve paid over the years to support NJ’s travel infrastructure? It’s unconscionable that NYers should have to pay to use NJ’s roads.

From pre-diabetes to Alzheimer’s disease in the cognitively normal, there is an ongoing push to label healthy individuals as sick. Who benefits from this and who is harmed? One of my favorite med journalism articles of 2024 dives into the debate. 🧵 1/4 latimes.com/science/story/…

One day’s notice, no severance—the DNC fights for workers, just not their own. Full statement below:

Medicine focuses a lot on the question “will this help my patient” but not on the question “when will it help my patient.” The latter becomes important as we age. We’ve developed a “time-to-benefit” tool on eprognosis.ucsf.edu to help answer this question. #FOAMed #meded

I wouldn't start infusing everyone w iron or even supplementing w pills, but I do expect Fe homeostasis to be a more common target for dementia research in the years ahead nature.com/articles/s4138…

Kariem Ezzat Shibley Lon S. Schneider, MD LogarithmicDis 🦋🇺🇸🇨🇦⛷️🔬🏨 Jason Cohen @Jeff_Browndyke Alberto J Espay Nicolas Villain / Moved to LinkedIn & BlueSky Seb Walsh Eric Widera, MD LTCShop.com Paul Jerome Lamont Robert Howard Madhav Thambisetty @KasperKepp Trey Bateman @PhilAlz Michael Schöll @VincentPlanche @StefanoSensi14 Gill Livingston @DrTFromKC @jfballenger @jasonkarlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD Howard Gleckman Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin Emmy Betz, MD, MPH 🇺🇲🩺🔬🤝❤️ Joanne Ryan Maggie Aime, BSN, RN | Freelance Writer Oskar Hansson David Jones Paul Thompson Ayisha Sharma Adam Dyer EU Medicines Agency NICE TGA Australia CDA-AMC MHRAgovuk U.S. FDA University of Copenhagen CancerRose Amyloid-Related Imaging Abnormalities in Clinical Trials of Gantenerumab in Early Alzheimer Disease jamanetwork.com/journals/jaman… via Mercè Boada Rovira et al

At #CTAD24, biomarker data suggest black and Hispanic people are less likely to have amyloid. Some suspect that comorbidities might contribute to cognitive decline. ow.ly/F0HG50Ubb22

New paper! Meta-analysis on cognitive intra-individual variability (IIV) in APOE-E4 carriers, MCI, and Alzheimer's dementia. link.springer.com/article/10.100…

Let’s talk about Donald Trump and his new Attorney General pick Pam Bondi, because boy do we have a story to tell

New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers 📄 doi.org/10.1002/dad2.7…

Covid Vaccine boosters work, even in those previously vaccinated!

These woods are dark and filled with trolls. I'm going to explore bluer places with clearer skies. Same handle 🦋

1/Controversy in radiology can get tense! The Mt Fuji sign for tension pnemocephalus is under scrutiny. When should you call it? A thread about imaging this important neurosurgery complication

You can get anything you want at #AlicesRestaurant Now I'm going back to Bsky

Does this look right to you? Let me take you down a rabbit hole to illustrate how a network of interlacing problems in Alzheimer’s disease research ethics impacts our progress on this disease.