🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Season 7 of our Front Row Lecture Series celebrated Scripps Research’s centennial with groundbreaking talks from our world-class scientists. 🌟 From neuroscience to global health, here’s a look at the remarkable discoveries shaping the future of science and medicine. ⬇️ (1/10)

Congrats to our grad students who pitched therapeutic targets at this year's Scripps Research Graduate Program Drug Discovery Shark Tank - particularly Shelby Shelby Ferrier and Morgan Morgan Gee on their winning proposal to target Cholera toxin subunit B, which raised $4 million!

Scripps Research Assoc. Prof. Anne Hanneken and UCSD Engineering Prof. Shadi Dayeh are part of a national team developing advanced techniques to revive donor eyes and regenerate optic nerves, with the potential to make vision-restoring transplants a reality. ow.ly/7e1m50Ul6Hv

My lab at Calibr-Skaggs/Scripps Research is hiring a Biophysicist, the candidate will characterize molecular interactions between Proteins and DEL screening SM/Peptide hits using SPR. All with experience using SPR are welcome to apply! Postdoctoral Associate, Biophysics | Calibr

Front Cover: HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores (ChemBioChem 4/2025) - Freeman - 2025 - ChemBioChem - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs | ACS Chemical Biology pubs.acs.org/doi/full/10.10… Provocative observations made in wonderful collaborations that reveal an exclusive protein-mediated prodrug activation in cancer cells

In a new op-ed for The San Diego Union-Tribune, Scripps Research President & CEO Pete Schultz explains how changes to federal science funding could impact biomedical research, innovation & San Diego’s life sciences ecosystem. sandiegouniontribune.com/2025/02/25/opi…

For years, ulcerative colitis was thought to be just inflammation. What if that’s wrong? In our latest Q&A, Amy Lee Lightner, MD explains why hidden scarring (fibrosis) may be the missing piece in treating UC—and how earlier intervention could change everything. ow.ly/OZhV50VfePV

Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening biorxiv.org/content/10.110… #biorxiv_biochem

Out today in ACS Publications Chem Bio, we uncovered a potential therapeutic resistance mechanism to TEAD inhibitors through direct competition of the binding pocket with increased levels of Palmitoyl-CoA. Check it out now! pubs.acs.org/doi/full/10.10…

A 2-for-1 resistance mechanism! Inspired by our colleague Michael Erb, Kayla Nutsch, PhD demonstrates that increased levels of acyl-CoAs not only promote resistance to active site HAT inhibitors but TEAD inhibitors as well. pubs.acs.org/doi/full/10.10…

Congrats to Prof. Dale Boger (BogerLab), who was awarded the 2025 Chemical Pioneer Award for his seminal work in natural product synthesis and molecular design. With 625+ papers and 300+ trainees, his research has shaped modern medicinal chemistry. More: ow.ly/Van750VAikE

WATCH TODAY at 10: We're celebrating 61 new PhDs in the chemical and biological sciences today at our 33rd Commencement! Watch live and see the face of the future of biomedical research and discovery. Register at: scripps.edu/graduation

We’re still buzzing from Commencement! We asked our new PhDs: How does it feel crossing the stage and what’s next after Scripps Research Graduate Program? 🎓✨

A new paper used reactivity-based metabolomics to show that methylglyoxal and its main metabolite lactoylglutathione react rapidly with cysteines to generate L- and D-lactoylated thioesters suggesting an additional pathway to enable protein lactoylation nature.com/articles/s4158…

This May, Scripps Research's Skaggs Graduate School awarded doctoral degrees to its 33rd graduating class. Professors and faculty share their wisdom to the 61 students who graduated this year. Watch now: youtu.be/KVXoWlbP1HU?si…

Calibr-Skaggs has dosed the first patient in a phase 1 trial evaluating CLBR001 + ABBV-461, a novel switchable CAR-T cell therapy for metastatic breast cancer. The therapy is being tested in solid tumors for the first time, in collaboration with @AbbVie. ow.ly/TOpA50Wb1QG

Fubylation as a Druggable Ubiquitin-Like Conjugation System Controlling Hippo Pathway Activity biorxiv.org/content/10.110… #biorxiv_biochem

One of the wildest MOAs to come out of our lab. A small molecule activator of YAP targets FUBI, a ubiquitin like protein that regulates Hippo pathway activity. Check out our WIP preprint. Thesis work of Maya Bulos biorxiv.org/content/10.110…

As humans age, the body’s ability to repair and replace tissue declines, resulting in illness and infirmity. This begs the question: How can science and medicine help people around the globe stay healthy as they live longer? To address this pressing need, scientists from the