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Emerging Frontiers in Bivalent Degraders: Mikko Taipale, Riccardo Sabatini, and Michael Erb will address this topic at the AACR Conference on Optimizing Therapeutic Efficacy and Tolerability through Chemistry (Dec 9-11, Toronto). bit.ly/3Yyl1X6 #AACRchem24 #AACRCICR

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Dodger Stadium is ready for the World Series 🎨 (via @LasMayores)

The Dawgs are feeling it.

Nice writeup in ⁦Nature Chemical Biology⁩ of key themes in the science covered at our Symposium celebrating the opening of Dundee’s CeTPD ⁦Centre for Targeted Protein Degradation⁩ “Degradation in Focus”, by David Zollman and Kirsten McAulay nature.com/articles/s4158…

Go Dodgers!

The first BTC trial to target AML MRD with combination of menin and BCL2 inhibition is now open! Huge team effort and more exciting trials for MRD to come. Goal is to better measure, understand and treat MRD

A small molecule that reshapes the chromatin dynamics of FOXA1 dlvr.it/TG3RWr

Check out this thoughtful Preview from Billy on our recent manuscript in Molecular Cell. Thanks Billy!

New cysteine warhead from ⁦Michael Bollong⁩ lab ⁦Scripps Research⁩ : Scalable Thiol Reactivity Profiling Identifies Azetidinyl Oxadiazoles as Cysteine-Targeting Electrophiles | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Interesting paper by the group of Michael Bollong of Scripps Research in J. Am. Chem. Soc.. A high-throughput assay for cysteine-reactive electrophiles based on luciferase activity allows identification of azetidinyl oxadiazoles as cysteine-reactive electrophiles. pubs.acs.org/doi/10.1021/ja…

After a half-day at school, my eldest just bumped into Reza Ghadiri, BogerLab, and Ben Cravatt within the space of 5 min. His chemical education is complete.

Thanks for chairing a great session Katherine, this was too much fun!

Really enjoyed this session and conference, thanks AACR for hosting a great program!

The juice is worth the squeeze. Elegant use of dTAG to model KRAS degradation in vivo, for therapeutic hypothesis validation by Cris Mayor-Ruiz and colleagues.

Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs | ACS Chemical Biology pubs.acs.org/doi/full/10.10… Provocative observations made in wonderful collaborations that reveal an exclusive protein-mediated prodrug activation in cancer cells

Check out this very cool extension of our work from the Bollong Group!

Hope to see many of you for Part 3 of the "Chemistry to the Clinic" series today at 2:30p!

The educational day at #AACR25 was again well-invested time thanks to the program committee selecting highly relevant topics. Below some highlights from Dan Nomura, Michael Erb, The Hackenberger Group & Raffaele Colombo about degrader identification & designing antibody-drug conjugates.

Yesterday's intractable targets session was a great success thanks to lively talks from Dan Nomura and Xiaoyu Zhang. Big thanks to CICR for putting together some really great topics.