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Y'all. Seriously. Hardly anyone even understands the unbelievable depth of Tolkien's linguistic genius. If ever there was an artist just straight up making jokes that only he would ever get, omg. So get this, it's epic. You know the "Brandywine River" in Lord of the Rings?

It’s easy to underestimate the economic catastrophe of the last 16 years because it’s been gradual. But imagine we’d actually grown at 2% a year since 2008 and then lost it all at once this year: it would be a collapse of >30% Hard to overstate how radical we need to be now

For the media class the apex of politics isn’t being a prosperous, socially just, well run country in the North Atlantic. No, it’s cosplaying being a mid 20th century imperial power. They genuinely all want to be in the West Wing. For them - this is as good as it gets.

Labour can't be trusted on defence.

Roman busts brought to life with AI 1. Trajan

I don’t think I’ve listened to a single budget in the last ten years in which the price of a pint hasn’t been reduced in some way. And yet, for some reason, when I bought two of them last week it cost me £15.20.

I'm constantly amazed at how many "expert" network interviews are fake. People just read a company website, claim to have worked with the company and rake in $$ talking to VCs.

For once "Kafkaesque", a word that can be misused, is spot on. The key theme of his novel The Trial is that the accused is never told what his offence is, and nor is the reader.

Never change, Daily Telegraph

Thanks for clarifying Steven Swinford

"Or Britain could keep on with the present charade. Tories want growth, but not if it means building things, aligning with Europe, or much exposure to China. Labour wants growth, but not if it incommodes the unions, or “leaves people behind” or some such NGO press release

How big a market do early stage VCs think there actually is for protein foundation models? Remember, the key cost and hurdle is clinical trails, not a lack of molecules to try drugging people with. (Side note: we need new targets and that's what Relation is about)

Excellent piece summarizing the amyloid fraud that's set back progress in Alzheimer's by over a decade. worksinprogress.news/p/a-review-of-…

When I was in govt Dominic Cummings drove the creation of ARIA to revolutionise govt funded research - I'm now v excited that we can talk about the work Lindus Health is doing with them on "Transforming clinical trial design using safe and reliable AI"!

Got to think that medieval battles looked more like this than the choreographed fights in films.

I've been called a lot of things, but "EA-aligned" is by far the worst

I love this country. I love London with everything I’ve got. It’s the greatest city on Earth or at least, it used to be. And I’ll tell you this now: anyone who says London is safer today than it was ten, fifteen years ago is lying through their teeth. I’ve worked these streets

It's not just IPOs - unfortunately pretty much every other founder I speak to is at least thinking about leaving the UK.