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Excited to share our new study with the Müller and SchullerJM labs, online @nature: nature.com/articles/s4158… This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of the enzyme HDCR 🍩 1/🧵

Glad to be a part of the SLFN11 story with Felix Metzner, Simon Wenzl and Katja Lammens in hopfnerlab at Gene Center Munich. Now online at Nature Communications.

Released today EMDB - EMPIAR @EBI & Protein Data Bank, & published Nature Communications, #CryoEM structures of the Human Schlafen-11 dimer apoenzyme. Study by F. J. Metzner et al., from Gene Center Munich @ 2.8 Å resolution.

Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into #protein molecules, which can have tens of thousands of atoms. ow.ly/Txn750LShFp

Fast cryo-electron tomography data acquisition to determine molecular structures in situ nature.com/articles/s4159…

The saga of carbonic anhydrase inhibitors continues - by using three different approaches we were exploring the potential exosite of carbonic anhydrases. Fruitful collaboration at IOCB Prague. Out now at RSC Medicinal Chemistry. pubs.rsc.org/en/content/art…

Check out our newest publication. Great work by Franziska Kunert and Felix Metzner! Thanks to all authors for the team effort. Markus Höpfler PfanderLab S.Eustermann et al. Structural mechanism of extranucleosomal DNA readout by the INO80 complex science.org/doi/10.1126/sc…

Glad to help regarding better understading of B–H⋯π and C–H⋯π hydrogen interactions on carbonic anhydrase II/carborane-based inhibitors - combination of X-ray crystallography and quantum-chemical calculations. IOCB Prague IIC Řež-Prague @nekwajz

Here's a thread about our recent eukaryotic RQC publication in Molecular Cell, which was my last project in the Beckmann Lab. Thanks to Inada Lab and all co-authors!

The 1st international Schlafen (SLFN) meeting was held Broad Institute this week. Amazing to meet colleagues all working in an under-researched group of genes/proteins. Can’t wait for the next…..#slfn #genetics #schlafen #sleep

Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the EustermannLab EMBL and all authors!!! science.org/doi/10.1126/sc…

@FASEB #HNASRC #Helicase23 is a wrap. Had a great time connecting with old friends, meeting some great new folks, and learning loads about RNA and DNA helicases. What a great turnout and lineup! Looking forward to #Helicase25!

Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in NSMB.com. Mammoth effort led by Helge Paternoga and Caillan Crowe-McAuliffe reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... nature.com/articles/s4159…

In our next meeting #MunichRNA20M, we will hear the amazing RNA science of Yung-Li Chen from ME Torres-Padilla lab (@Helmholtz_MUC) and Michael Kugler from hopfnerlab (Universität München). Hope to see you there! 📅20/03/24 3pm 📍Max Planck Institute of Biochemistry (MPIB)

An inspiring example! Petr Těšina moved back to Czechia from Germany (LMU) when he won an ERC Starting Grant. It allows him to set up a research team at CEITEC and take his cutting-edge to new levels. Petr Těšina

The #Schlafen11 protein, identified as sensor for single stranded DNA #ssDNA, may be part of new class of pattern recognition receptors. Read more: scim.ag/7kA

Thanks to all the attendees, speakers and discussion leaders that made the 2024 3DEM GRC grc.org/three-dimensio… an exciting and memorable event! #3dem

Join us in our next #MunichRNA19F! 📍 Max Planck Institute of Biochemistry (MPIB) 📅 19/02/2025 We will hear amazing talks from Shuyao Sha (kusterlab (Inactive) ), Laura Martens (@lauradmartens.bsky.social) (gagneurlab), Michael Kugler (hopfnerlab), Marc Schmitt-Supprian. Don't miss it! 🧬😀